Prof Mandigout Stéphane, University of Limoges, HAVAE UR20217, 123 Av Albert Thomas, 87060 Limoges, France,
J Frailty Aging. 2024;13(3):240-247. doi: 10.14283/jfa.2024.53.
The study investigates the correlation between muscle mass and physical activity level measured objectively and subjectively in older adults who fall or are at high risk of falling.
FITNESS (Fall Interest to Target Newly Sarcopenic Society) is a multi-center (French university hospitals of Angers, Lille, Limoges and Orléans), cross-sectional, observational study of routine care within a French multidisciplinary hospital consultation. Inclusion criteria were ≥ 75 years old, living at home and consulting for fall or gait disorder. A standardized geriatric assessment, muscle mass evaluation by impedancemetry, physical activity by continuous actimetry (5 days) and Incidental and Planned Exercise Questionnaire (IPEQ) were performed at patient inclusion.
170 people aged 75 and over were included in the FITNESS study (mean age 82.9 ±4.7 years, women 72.9%). Muscle mass (whole body and lower limbs) correlated with active energy expenditure (AEE, ρ whole body = 0.32, p-value < 0.001; ρ lower limbs = 0.25, p-value = 0.003), but not with number of daily steps, nor with IPEQ score. Multivariate analysis of whole-body muscle mass showed a positive and significant association with AEE and albumin levels and for lower limb muscle mass, a positive association with AEE and Charlson.
This study suggests that in the particular population of older adults who fall and/or are at high risk of falling, loss of muscle mass correlates with reduced physical activity. So subjects who fall or at high risk of falling constitute a special group for whom the fight against sedentary lifestyles and the maintenance of physical activity should be a dual priority.
本研究旨在调查肌肉质量与客观和主观测量的老年人身体活动水平之间的相关性，这些老年人有跌倒或高跌倒风险。
FITNESS（跌倒兴趣目标新肌少症社会）是一项多中心（法国安格斯、里尔、利摩日和奥尔良的大学附属医院）、常规护理的横断面、观察性研究，该研究在法国多学科医院咨询中进行。纳入标准为≥75 岁，居住在家中，因跌倒或步态障碍就诊。在患者纳入时进行了标准化的老年评估、肌肉质量阻抗测量、连续运动计（5 天）和偶然和计划锻炼问卷（IPEQ）评估。
共有 170 名 75 岁及以上的人参加了 FITNESS 研究（平均年龄 82.9±4.7 岁，女性 72.9%）。肌肉质量（全身和下肢）与主动能量消耗（AEE）相关（ρ全身=0.32，p 值<0.001；ρ下肢=0.25，p 值=0.003），但与每日步数或 IPEQ 评分无关。全身肌肉质量的多元分析显示，与 AEE 和白蛋白水平呈正相关，与下肢肌肉质量呈正相关，与 AEE 和 Charlson 呈正相关。
本研究表明，在跌倒和/或有高跌倒风险的老年人特殊人群中，肌肉质量的丧失与身体活动减少相关。因此，跌倒或有高跌倒风险的患者构成了一个特殊群体，对于他们来说，对抗久坐不动的生活方式和保持身体活动应该是双重优先事项。
