School of Allied Health, Human Services and Sport, La Trobe University, Plenty Road, Kingsbury Dr, Bundoora, VIC 3086, Australia.
Non-communicable and implementation science lab, Baker Heart and Diabetes Institute, Alice Springs, Australia.
Curr Diab Rep. 2024 Sep;24(9):207-215. doi: 10.1007/s11892-024-01548-0. Epub 2024 Jul 31.
To update the evidence of lifestyle interventions for the prevention of type 2 diabetes mellites (T2DM) in adults, particularly in the Asia Pacific region. The key questions to ask are: 1) How effective are lifestyle interventions in preventing T2DM among at-risk adults in the Asia Pacific Region? 2)What are the key characteristics of the implementation of lifestyle interventions for diabetes prevention?
Lifestyle interventions for the prevention of T2DM have been suggested to be effective. There is evidence of ethnic differences in some glycaemic and anthropometric outcomes. The meta-analysis suggested a significant result in reducing waist circumference (standardised mean difference - 019, 95%CI ( -0.31, -0.06)), and no significant effects in other outcomes. However, the implementation outcomes suggested lifestyle intervention might be a cost-effective and sustainable approach in T2DM particularly in countries in the Asia Pacific Region. The focus of lifestyle intervention in the Asia Pacific Region should not only lie in the effectiveness of the trial but a thorough evaluation of the implementation outcomes, as well as cultural adaptations, with the support of all stakeholders through all stages of the implementation.
更新生活方式干预预防成人 2 型糖尿病（T2DM）的证据，特别是在亚太地区。需要回答的关键问题是：1）生活方式干预在预防亚太地区高危成年人 T2DM 方面的效果如何？2）预防糖尿病的生活方式干预的关键实施特征是什么？
生活方式干预预防 T2DM 被认为是有效的。在一些血糖和人体测量学结果方面存在种族差异的证据。荟萃分析表明，在减少腰围方面有显著效果（标准化均数差-0.19，95%CI（-0.31，-0.06）），而其他结果则没有显著影响。然而，实施结果表明，生活方式干预可能是一种具有成本效益和可持续性的 T2DM 防治方法，特别是在亚太地区的国家。亚太地区生活方式干预的重点不仅应放在试验的有效性上，还应全面评估实施结果，以及文化适应性，并在实施的所有阶段得到所有利益相关者的支持。
