Shanghai University of Sport, Shanghai 200438, China; Shanghai Deji Hospital, Qingdao University, Putuo District, Shanghai 200331, China.
Department of Endocrinology, Shidong Hospital, Yangpu District, Shanghai 200433, China.
Exp Gerontol. 2023 Aug;179:112250. doi: 10.1016/j.exger.2023.112250. Epub 2023 Jun 29.
This randomized controlled trial aimed to study the effects of Yijinjing plus Elastic Band Resistance exercise on intrahepatic lipid (IHL), body fat distribution, glucolipid metabolism and biomarkers of inflammation in middle-aged and older people with pre-diabetes mellitus (PDM).
34 PDM participants (mean age, 62.62 ± 4.71 years; body mass index [BMI], 25.98 ± 2.44 kg/m) were randomly assigned to the exercise group (n = 17) or control group (n = 17). The exercise group performed moderate-intensity Yijinjing and Elastic Band Resistance training 5 times per week for 6 months. The control group maintained their previous lifestyle. We measured body composition (body weight and body fat distribution), IHL, plasma glucose, lipid and the homeostatic model assessment of insulin resistance (HOMA-IR), inflammatory cytokines at baseline and 6 months.
Compared with baseline, exercise significantly reduced IHL (reduction of 1.91 % ± 2.61 % vs an increase of 0.38 % ± 1.85 % for controls; P = 0.007), BMI (reduction of 1.38 ± 0.88 kg/m vs an increase of 0.24 ± 1.02 kg/m for controls; P = 0.001), upper limb fat mass, thigh fat mass and whole body fat mass. Fasting glucose, HOMA-IR, plasma total cholesterol (TC), and triglyceride (TG) were decreased in the exercise group (P < 0.05). There were no effects of exercise on liver enzyme levels and inflammatory cytokines. The decrease in IHL was positively correlated with the decreases in BMI, body fat mass and HOMA-IR.
Six months of Yijinjing and resistance exercise significantly reduced hepatic lipids and body fat mass in middle-aged and older people with PDM. These effects were accompanied by weight loss, improved glycolipid metabolism and insulin resistance.
本随机对照试验旨在研究易筋经加弹力带抗阻运动对中年及老年糖尿病前期患者（PDM）的肝内脂质（IHL）、体脂分布、糖脂代谢及炎症标志物的影响。
34 名 PDM 患者（平均年龄 62.62±4.71 岁；体重指数 [BMI] 25.98±2.44kg/m）被随机分为运动组（n=17）和对照组（n=17）。运动组每周进行 5 次中等强度的易筋经和弹力带抗阻训练，共 6 个月。对照组保持以前的生活方式。我们在基线和 6 个月时测量了身体成分（体重和体脂分布）、IHL、血浆葡萄糖、血脂和稳态模型评估的胰岛素抵抗（HOMA-IR）、炎症细胞因子。
与基线相比，运动组 IHL 显著降低（减少 1.91%±2.61%，对照组增加 0.38%±1.85%；P=0.007），BMI（减少 1.38±0.88kg/m，对照组增加 0.24±1.02kg/m；P=0.001），上肢脂肪量、大腿脂肪量和全身脂肪量也显著降低。运动组空腹血糖、HOMA-IR、血浆总胆固醇（TC）和甘油三酯（TG）降低（P<0.05）。运动对肝酶水平和炎症细胞因子没有影响。IHL 的降低与 BMI、体脂量和 HOMA-IR 的降低呈正相关。
6 个月的易筋经加抗阻运动可显著降低中年及老年 PDM 患者的肝内脂质和体脂量。这些效果伴随着体重减轻、改善糖脂代谢和胰岛素抵抗。
