Viscoli C, Gargani G, Facco F, Mantero E, Tuo P, Giacchino R, Campelli A, Nantron M, Perlino G
Int J Clin Pharmacol Ther Toxicol. 1985 Nov;23(11):629-34.
The efficacy of ceftazidime in the treatment of infections in compromised children was evaluated in 80 such episodes occurring in 64 patients with various underlying diseases. Among the patients treated, 9 were newborns with severe neonatal distress, 21 were children with cancer and neutropenia, 8 were surgical patients, 22 had cystic fibrosis and 4 were suffering from meningitis. The following types of infections were treated: 19 bacteriologically documented and 8 possible septicemias (the latter only in newborns and neutropenic cancer patients); 2 severe upper respiratory tract infections in cancer patients; 8 soft tissue or skin infections; 1 cholangitis; 1 pneumonia; 1 osteomyelitis; 1 mediastinitis; 35 infectious exacerbations of underlying pulmonary disease in cystic fibrosis patients; and 4 meningitides. In almost all cases ceftazidime was administered intravenously in combination with an aminoglycoside. In 2 cases it was also given intrathecally or intraventricularly. Bacteriological documentation was achieved in 70 out of 80 episodes. A successful outcome was obtained in 79% of the cases with slight and statistically nonsignificant differences between groups of patients with different etiological patterns in terms of prevalence of gram-positive microorganisms. Tolerance of the treatment was uniformly good, only one patient showing a mild, transient transaminase elevation.
在64例患有各种基础疾病的患儿中发生了80次感染事件，以此评估了头孢他啶治疗免疫功能低下儿童感染的疗效。在接受治疗的患者中，9例为患有严重新生儿窘迫的新生儿，21例为患有癌症和中性粒细胞减少症的儿童，8例为外科手术患者，22例患有囊性纤维化，4例患有脑膜炎。治疗了以下类型的感染：19例有细菌学记录的感染和8例可能的败血症（后者仅见于新生儿和中性粒细胞减少的癌症患者）；2例癌症患者的严重上呼吸道感染；8例软组织或皮肤感染；1例胆管炎；1例肺炎；1例骨髓炎；1例纵隔炎；35例囊性纤维化患者潜在肺部疾病的感染加重；以及4例脑膜炎。几乎在所有病例中，头孢他啶均与氨基糖苷类药物联合静脉给药。2例还进行了鞘内或脑室内给药。80次感染事件中有70次获得了细菌学记录。79%的病例取得了成功结果，不同病因类型的患者组在革兰氏阳性微生物患病率方面存在轻微且无统计学意义的差异。治疗耐受性总体良好，只有1例患者出现轻度、短暂的转氨酶升高。
