Boner A L, Castellani C, Fostini R, Padovani E
Int J Clin Pharmacol Ther Toxicol. 1986 Jun;24(6):333-6.
Ceftazidime (C) is a cephalosporine active against Gram-positive and especially negative bacteria. The aim of the study was to evaluate efficacy and tolerance of C in the treatment of children suffering from infections previously treated unsuccessfully with different antibiotics. We examined 20 children, administering a dosage of C 30 to 100 mg/kg intravenously or intramuscularly for a mean treatment duration of 8.6 days. A favorable response was observed in all the children: of the 20 patients 13 were cured and 7 improved. A transient elevation of liver enzymes was noted in three children. The study confirms the efficacy of C in the treatment of severe infections. Since 9 of the 20 patients were neonates, we suggest the possible role of C in the newborns' infections.
头孢他啶（C）是一种对革兰氏阳性菌尤其是革兰氏阴性菌有效的头孢菌素。本研究的目的是评估头孢他啶在治疗先前使用不同抗生素治疗失败的感染儿童中的疗效和耐受性。我们检查了20名儿童，静脉内或肌肉内给予30至100mg/kg的头孢他啶剂量，平均治疗持续时间为8.6天。所有儿童均观察到良好反应：20例患者中13例治愈，7例好转。3名儿童出现肝酶短暂升高。该研究证实了头孢他啶在治疗严重感染中的疗效。由于20例患者中有9例是新生儿，我们认为头孢他啶在新生儿感染中可能发挥作用。
