Senay E C
Int J Addict. 1985 Jun-Jul;20(6-7):803-21. doi: 10.3109/10826088509047754.
This paper reviews the world literature on methadone. Methadone has been used in hundreds of thousands of patients, in disparate social, economic, cultural, and geographic situations; it has been evaluated in scores of studies. The large majority of evaluations demonstrate that opioid use, criminality, and general health status are affected positively in many addicts. Smaller gains in job and family functions are noted. Alcoholism and multiple drug use complicate treatment for some addicts. Despite the positive data, public opinion remains negative about this treatment. The use of methadone in withdrawal from opioid dependence and in pregnancy complicated by opioid dependence is discussed.
本文综述了关于美沙酮的世界文献。美沙酮已应用于数十万患者，涉及不同的社会、经济、文化和地理环境；它已在大量研究中得到评估。绝大多数评估表明，许多成瘾者的阿片类药物使用、犯罪行为和总体健康状况都受到了积极影响。在工作和家庭功能方面也有较小的改善。酗酒和多种药物使用使一些成瘾者的治疗变得复杂。尽管有这些积极的数据，但公众对这种治疗的看法仍然负面。本文还讨论了美沙酮在阿片类药物依赖戒断和阿片类药物依赖合并妊娠中的应用。
