Hamed Eslam M, Fung Fun Man, Li Sam F Y
Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Singapore.
Department of Chemistry, Faculty of Science, Ain Shams University, Abbassia, Cairo 11566, Egypt.
ACS Sens. 2024 Aug 23;9(8):3840-3847. doi: 10.1021/acssensors.4c00630. Epub 2024 Jul 31.
Single-atom nanozymes (SANs) have become a breakthrough in atomically precise catalysis, which relies on the catalytic active site formed by the single-atom itself. From this angle, SANs and their advantages compared to natural enzymes as well as spaces for their application are emphasized. The SANs have outstanding control over their catalytic activities; this is compared with bulk materials and natural enzymes. The structure of the SANs has very promising potential for the next generation of biosensing and biomedical devices and environmental remediation. Although their capabilities are high, difficulties still arise. The specificity, scalability, biosafety, and catalysis mechanisms raise additional issues that require further research. We build up a vision of the perspectives of the better implementation of SANs, which are designed for diagnostic purposes, improving industrial technologies, and creating new sustainable technologies in the food processing industry. AI and machine learning systems may clarify the structure-performance relationship of SANs for improved material and process selectivity. The future of SANs is very promising, and by addressing these challenges and leveraging advancements in artificial intelligence and materials science, SANs have the potential to become powerful tools for a sustainable future.
单原子纳米酶（SANs）已成为原子精确催化领域的一项突破，其依赖于单原子自身形成的催化活性位点。从这个角度出发，强调了单原子纳米酶及其与天然酶相比的优势以及它们的应用空间。单原子纳米酶对其催化活性具有出色的控制能力；这与块状材料和天然酶进行了比较。单原子纳米酶的结构在下一代生物传感、生物医学设备及环境修复方面具有非常广阔的潜力。尽管它们性能卓越，但仍存在困难。特异性、可扩展性、生物安全性及催化机制引发了更多需要进一步研究的问题。我们构建了一个关于更好地应用单原子纳米酶的展望，这些应用旨在诊断目的、改进工业技术以及在食品加工业中创造新的可持续技术。人工智能和机器学习系统可能会阐明单原子纳米酶的结构 - 性能关系，以提高材料和工艺的选择性。单原子纳米酶的未来非常有前景，通过应对这些挑战并利用人工智能和材料科学的进步，单原子纳米酶有潜力成为实现可持续未来的强大工具。
