Meng Qian-Qian, Su Yi, Tong Shun-Yao, Peng Xing-Rong, Zhu Jun-Chen, Liu Ji-Kai
The Second Affiliated Hospital, Anhui University of Chinese Medicine, Hefei, People's Republic of China.
School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan, Hubei, People's Republic of China.
Nat Prod Res. 2024 Jul 31:1-10. doi: 10.1080/14786419.2024.2373963.
The , also known as "Feng Dan" have a crucial role in folk medicine to treat lumbar muscles strain, knee osteoarthritis and cervical spondylosis. In this study, four new phenolic compounds, specifically Paeoniaostiph A-E (-) phenolic compounds were characterised through spectroscopic techniques, including 1D and 2D NMR, HRESIMS, UV, IR, and electronic circular dichroism computations to explore their structures. Cytotoxicity and NO production inhibition of the new phenolic compounds were also studied. The results of the cytotoxicity experiment showed that compound is cytotoxic to two human cancer cell lines with IC values ranging from 13.3 to 13.5 μM. Compounds and showed certain inhibitory activity on NO production. This is the first report on isolating the components from natural sources.
该植物，也被称为“凤丹”，在民间医学中对治疗腰肌劳损、膝关节骨关节炎和颈椎病起着关键作用。在本研究中，通过光谱技术，包括一维和二维核磁共振、高分辨电喷雾电离质谱、紫外光谱、红外光谱以及电子圆二色性计算，对四种新的酚类化合物，即芍药ostiph A - E（-）酚类化合物进行了表征，以探究它们的结构。还研究了新酚类化合物的细胞毒性和一氧化氮生成抑制作用。细胞毒性实验结果表明，化合物对两种人类癌细胞系具有细胞毒性，半数抑制浓度值范围为13.3至13.5 μM。化合物 和 对一氧化氮生成表现出一定的抑制活性。这是首次从天然来源分离这些成分的报道。
