Boyde A, Jones S J
J Biomed Mater Res. 1985 Mar;19(3):199-224. doi: 10.1002/jbm.820190304.
We consider results from tissue culture studies and the comparative histology of mineralized tissues and other natural tissue interfaces which may have some relevance in understanding the abnormal biology of the immediate environment of an implant in bone. We discuss factors influencing setting, colonization, and migration on natural and artificial substrates by various cell types which may make or remove matrix near the implant. A knowledge of mechanisms of mineral and organic matrix destruction by osteoclasts and other cells must be important in addition to an understanding of the interaction of local and systemic hormones with bone cells. More studies of the role of the immune system in implant failure are urgently required.
我们考虑了组织培养研究的结果，以及矿化组织和其他天然组织界面的比较组织学，这些可能与理解植入物在骨中紧邻环境的异常生物学有关。我们讨论了各种细胞类型在天然和人工基质上的黏附、定植和迁移的影响因素，这些细胞类型可能在植入物附近形成或去除基质。除了了解局部和全身激素与骨细胞的相互作用外，了解破骨细胞和其他细胞破坏矿物质和有机基质的机制也很重要。迫切需要更多关于免疫系统在植入失败中作用的研究。
