Reddi A H
J Biomed Mater Res. 1985 Mar;19(3):233-9. doi: 10.1002/jbm.820190306.
The sequential cellular reactions in the interface of collagenous bone matrix implants are described. The multistep cascade in response to bone matrix implantation include: binding of fibrin and fibronectin to the implanted matrix, chemotaxis of cells, proliferation of fibroblasts, differentiation into chondroblasts, cartilage formation, vascular invasions, bone formation, remodeling, and bone marrow differentiation. The mechanisms of action is not known. However, several properties governing the implant-cell interface are described. It is possible that bone matrix is a suitable biomaterial with potential applications in periodontal and orthopedic practice.
描述了胶原骨基质植入物界面中的一系列细胞反应。对骨基质植入的多步骤级联反应包括：纤维蛋白和纤连蛋白与植入基质的结合、细胞趋化性、成纤维细胞增殖、分化为成软骨细胞、软骨形成、血管侵入、骨形成、重塑以及骨髓分化。其作用机制尚不清楚。然而，描述了一些控制植入物 - 细胞界面的特性。骨基质可能是一种适用于牙周和骨科实践的潜在生物材料。
