Center of Psychosomatic Medicine, Sichuan Provincial Center for Mental Health, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China; MOE Key Laboratory for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
Huaxi MR Research Center (HMRRC), Department of Radiology, Functional and Molecular lmaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Neurosci Biobehav Rev. 2024 Sep;164:105835. doi: 10.1016/j.neubiorev.2024.105835. Epub 2024 Jul 29.
Depression is a highly prevalent and debilitating mental disorder that often begins in adolescence. However, it remains unclear whether adults and adolescents with depression exhibit common or distinct brain dysfunctions during reward processing. We aimed to identify common and separable neurofunctional alterations during receipt of rewards and brain structure in adolescents and adults with depression. A coordinate-based meta-analysis was employed using Seed-based d mapping with permutation of subject images (SDM-PSI). Compared with healthy controls, both age groups exhibited common activity decreases in the right striatum (putamen, caudate) and subgenual ACC. Adults with depression showed decreased reactivity in the right putamen and subgenual ACC, while adolescents with depression showed decreased activity in the left mid cingulate, right caudate but increased reactivity in the right postcentral gyrus. This meta-analysis revealed shared (caudate) and separable (putamen and mid cingulate cortex) reward-related alterations in adults and adolescents with depression. The findings suggest age-specific neurofunctional alterations and stress the importance of adolescent-specific interventions that target social functions.
抑郁症是一种高发且使人虚弱的精神障碍，通常在青春期开始出现。然而，目前尚不清楚患有抑郁症的成年人和青少年在奖励处理过程中是否表现出共同或独特的大脑功能障碍。我们旨在确定患有抑郁症的青少年和成年人在接受奖励时以及大脑结构方面存在共同和可分离的神经功能改变。我们使用基于种子的弥散磁共振成像配准分析（SDM-PSI）进行基于坐标的荟萃分析。与健康对照组相比，两个年龄组在右侧纹状体（壳核、尾状核）和前扣带回亚区都表现出共同的活动减少。成年抑郁症患者的右侧壳核和前扣带回亚区反应性降低，而青少年抑郁症患者的左侧中央旁小叶、右侧尾状核活性降低，但右侧中央后回反应性增加。这项荟萃分析揭示了患有抑郁症的成年人和青少年中存在共享（尾状核）和可分离（壳核和中央旁小叶）的与奖励相关的改变。这些发现表明存在年龄特异性的神经功能改变，并强调了针对社交功能的青少年特异性干预的重要性。
