Department of Cardiology, The Second Affiliated Hospital of Kunming Medical University.
Department of Rehabilitation Medicine, The Second Affiliated Hospital of Kunming Medical University.
Int Heart J. 2024;65(4):713-722. doi: 10.1536/ihj.24-154.
Heart failure (HF) is a clinical syndrome caused by the progression of various cardiac diseases to severe stages, and exercise training plays a positive role in the development of HF. This study aimed to investigate the impact of different intensities of exercise training on HF rats.In this study, we established two HF rat models by intraperitoneal injection of isoproterenol at 2.5 mg/kg/day and abdominal aortic coarctation. After exercise training for 4 weeks, the heart weight/body weight ratio and echocardiography results were measured. Moreover, the regulatory effect of different exercise intensities on myocardial function in HF model rats was verified using tissue staining, western blotting, and reagent kits.Exercise training had a bidirectional adjust effect on HF. A running training program of 20 minutes/time had the most significant effect on improving myocardial function in HF rats, whereas exercise intensity of 40 minutes/time or 50 minutes/time did not significantly improve myocardial function in HF rats. Moreover, exercise intensities of 20 minutes/time and 30 minutes/time could reduce the expression levels of the HF markers NT-proBNP and BNP in rats, but the effect was more significant at a duration of 20 minutes/time. We also found that compared with other exercise intensities, 20 minutes/time exercise intensity could significantly improve myocardial fibrosis, promote cardiomyocyte autophagy, and reduce apoptosis in combating HF.Furthermore, an exercise intensity of 20 minutes/time can significantly ameliorate the progression of HF. However, the degree of significance of increasing exercise intensity in improving HF progression is weakened or has no significant effect.
心力衰竭（HF）是由各种心脏疾病进展到严重阶段引起的临床综合征，运动训练对 HF 的发展具有积极作用。本研究旨在探讨不同强度的运动训练对 HF 大鼠的影响。
在这项研究中，我们通过腹腔注射 2.5mg/kg/天的异丙肾上腺素建立了两种 HF 大鼠模型，并进行了 4 周的运动训练。测量心脏重量/体重比和超声心动图结果。此外，还通过组织染色、Western blot 和试剂盒验证了不同运动强度对 HF 模型大鼠心肌功能的调节作用。
运动训练对 HF 具有双向调节作用。20 分钟/次的跑步训练方案对改善 HF 大鼠的心肌功能效果最显著，而 40 分钟/次或 50 分钟/次的运动强度对 HF 大鼠的心肌功能没有显著改善作用。此外，20 分钟/次和 30 分钟/次的运动强度可以降低大鼠中 HF 标志物 NT-proBNP 和 BNP 的表达水平，但 20 分钟/次的效果更显著。我们还发现，与其他运动强度相比，20 分钟/次的运动强度可以显著改善心肌纤维化，促进心肌细胞自噬，减少细胞凋亡，从而对抗 HF。
此外，20 分钟/次的运动强度可以显著改善 HF 的进展。然而，增加运动强度对改善 HF 进展的显著程度减弱或没有显著效果。
