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评估急性创伤性脊髓损伤后钙调节失调的初步筛查方法:回顾性研究。

Evaluating initial screening practices for calcium dysregulation after acute traumatic spinal cord injury: a retrospective review.

机构信息

Department of Physical Medicine and Rehabilitation, VCU Health, Richmond, VA, USA.

Department of Internal Medicine, Division of Endocrinology, VCU Health, Central Virginia Veteran's Affairs Healthcare System, Richmond, VA, USA.

出版信息

Spinal Cord Ser Cases. 2024 Jul 31;10(1):54. doi: 10.1038/s41394-024-00663-0.

DOI:10.1038/s41394-024-00663-0
PMID:39085204
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11291971/
Abstract

OBJECTIVES

The purpose of this study was to determine the frequency of which calcium homeostasis markers are obtained in the acute setting after an initial traumatic spinal cord injury (TSCI).

DESIGN

Retrospective chart review of a limited data set linking ICD 10 codes designating TSCI to corresponding calcium homeostasis markers for patients with an initial chart encounter for TSCI.

SETTING

A level 1 trauma center in Virginia, United States METHODS: The statistical software SPSS was used to calculate summary statistics including frequency, mean, and standard deviation for calcium homeostasis markers (basic metabolic panel, magnesium, spot urine calcium, testosterone panel, liver function tests, Vitamin D level, C-telopeptide, parathyroid hormone, celiac panel, DXA imaging report) as well as the mean and standard deviation for time to first check of the marker.

RESULTS

Most markers were not obtained besides calcium. Only 10 of 80 (12.5%) of subjects had a Vitamin D level (mean 28, SD 23) checked during acute admission (mean days to check 1.5, SD 1.6), with most other markers checked much less frequently.

CONCLUSIONS

Most calcium homeostasis markers were not checked on acute admission after TSCI. Future studies on implementing a standardized calcium homeostasis marker protocol for monitoring and potential medical intervention should be explored.

摘要

目的

本研究旨在确定在初次创伤性脊髓损伤(TSCI)后的急性治疗环境中,钙稳态标志物的获取频率。

设计

回顾性图表审查,将 ICD-10 代码指定为 TSCI 的有限数据集与 TSCI 初始图表就诊患者的钙稳态标志物相关联。

地点

美国弗吉尼亚州的 1 级创伤中心

方法

使用统计软件 SPSS 计算钙稳态标志物(基本代谢面板、镁、尿液钙点、睾酮面板、肝功能检查、维生素 D 水平、C 端肽、甲状旁腺激素、乳糜泻面板、DXA 成像报告)的频率、均值和标准差,以及标志物首次检查的均值和标准差。

结果

除钙外,大多数标志物都未被检测到。在急性入院期间,仅 80 名患者中的 10 名(12.5%)进行了维生素 D 水平(平均 28,标准差 23)检查(平均检查天数 1.5,标准差 1.6),其他大多数标志物检查频率要低得多。

结论

TSCI 后,在急性入院期间,大多数钙稳态标志物都未被检测到。应探索实施标准化钙稳态标志物监测和潜在医学干预方案的未来研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a822/11291971/1df5a53f0b0a/41394_2024_663_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a822/11291971/2e0191a3fc2b/41394_2024_663_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a822/11291971/1646529e3bed/41394_2024_663_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a822/11291971/1df5a53f0b0a/41394_2024_663_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a822/11291971/2e0191a3fc2b/41394_2024_663_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a822/11291971/1646529e3bed/41394_2024_663_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a822/11291971/1df5a53f0b0a/41394_2024_663_Fig3_HTML.jpg

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本文引用的文献

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Front Nutr. 2023 Feb 14;10:920998. doi: 10.3389/fnut.2023.920998. eCollection 2023.
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Prevalence of vitamin D deficiency in patients with spinal cord injury at admission: a single-centred study in the UK.英国单中心研究:入院时脊髓损伤患者维生素 D 缺乏症的患病率。
J Nutr Sci. 2023 Feb 20;12:e24. doi: 10.1017/jns.2023.12. eCollection 2023.
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Prevalence of an insufficient vitamin D status at the onset of a spinal cord injury - a cross-sectional study.
脊髓损伤发病时维生素D状态不足的患病率——一项横断面研究
Spinal Cord. 2023 Mar;61(3):211-217. doi: 10.1038/s41393-022-00873-z. Epub 2022 Dec 29.
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Vitamin D Promotes Remyelination by Suppressing c-Myc and Inducing Oligodendrocyte Precursor Cell Differentiation after Traumatic Spinal Cord Injury.维生素 D 通过抑制 c-Myc 和诱导少突胶质前体细胞分化促进创伤性脊髓损伤后的髓鞘再生。
Int J Biol Sci. 2022 Aug 29;18(14):5391-5404. doi: 10.7150/ijbs.73673. eCollection 2022.
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Endocrinological and inflammatory markers in individuals with spinal cord injury: A systematic review and meta-analysis.脊髓损伤患者的内分泌和炎症标志物:系统评价和荟萃分析。
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Cureus. 2021 Mar 9;13(3):e13791. doi: 10.7759/cureus.13791.
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Spinal Cord. 2017 May;55(5):428-434. doi: 10.1038/sc.2016.155. Epub 2016 Nov 8.
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Influence of season, ethnicity, and chronicity on vitamin D deficiency in traumatic spinal cord injury.季节、种族和病程对创伤性脊髓损伤患者维生素D缺乏的影响。
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