Absence of ABL1 exon 2-encoded SH3 residues in BCR::ABL1 destabilizes the autoinhibited kinase conformation and confers resistance to asciminib.
作者信息
Leyte-Vidal Ariel, DeFilippis RosaAnna, Outhwaite Ian R, Kwan Isabelle, Lee Ji Young, Leavitt Carlyn, Miller Kaeli B, Rea Delphine, Rangwala Aziz M, Lou Kevin, Patel Suhana, Alvarez Ailin, Shokat Kevan M, Bahar Ivet, Seeliger Markus A, Shah Neil P
机构信息
Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, CA, 94143, USA.
Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL, 33101, USA.
出版信息
Leukemia. 2024 Sep;38(9):2046-2050. doi: 10.1038/s41375-024-02353-0. Epub 2024 Jul 31.
Abstract
摘要
Zotero 插件