未治疗的首发重性抑郁障碍患者杏仁核亚区的异常动态功能连接。
Abnormal dynamic functional connectivity of amygdalar subregions in untreated patients with first-episode major depressive disorder.
机构信息
From the Huaxi MR Research Centre (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Qiu, Chen, Lui, Huang, Gong); the Department of Radiology, The Second People's Hospital of Yibin, Yibin, China (Qiu); the National Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China (Xia, Yuan, He); the Beijing Key Laboratory of Brain Imaging and Connectomics, Beijing Normal University, Beijing, China (Xia, He); the IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China (Xia, He); the Department of Psychiatry, State Key Lab of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China (Kuang); the Department of Oncology, State Key Lab of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China (Bi); the National Engineering Research Centre for Biomaterials, Sichuan University, Chengdu, Sichuan, China (Ai, Gu).
出版信息
J Psychiatry Neurosci. 2018 Jul;43(4):262-272. doi: 10.1503/jpn.170112.
BACKGROUND
Accumulating evidence supports the concept of the amygdala as a complex of structurally and functionally heterogeneous nuclei rather than as a single homogeneous structure. However, changes in resting-state functional connectivity in amygdalar subregions have not been investigated in major depressive disorder (MDD). Here, we explored whether amygdalar subregions - including the laterobasal, centromedial (CM) and superficial (SF) areas - exhibited distinct disruption patterns for different dynamic functional connectivity (dFC) properties, and whether these different properties were correlated with clinical information in patients with MDD.
METHODS
Thirty untreated patients with first-episode MDD and 62 matched controls were included. We assessed between-group differences in the mean strength of dFC in each amygdalar subregion in the whole brain using general linear model analysis.
RESULTS
The patients with MDD showed decreased strength in positive dFC between the left CM/SF and brainstem and between the left SF and left thalamus; they showed decreased strength in negative dFC between the left CM and right superior frontal gyrus ( < 0.05, family-wise error-corrected). We found significant positive correlations between age at onset and the mean positive strength of dFC in the left CM/brainstem in patients with MDD.
LIMITATIONS
The definitions of amygdalar subregions were based on a cytoarchitectonic delineation, and the temporal resolution of the fMRI was slow (repetition time = 2 s).
CONCLUSION
These findings confirm the distinct dynamic functional pathway of amygdalar subregions in MDD and suggest that the limbic-cortical-striato-pallido-thalamic circuitry plays a crucial role in the early stages of MDD.
背景
越来越多的证据支持杏仁核作为一个结构和功能上异质的核团复合体的概念，而不是一个单一的均质结构。然而，在重度抑郁症（MDD）中，尚未研究杏仁核亚区静息态功能连接的变化。在这里，我们探讨了杏仁核亚区（包括基底外侧、中央内侧（CM）和浅层（SF）区域）是否表现出不同的动态功能连接（dFC）特性的破坏模式，以及这些不同的特性是否与 MDD 患者的临床信息相关。
方法
纳入 30 名未经治疗的首发 MDD 患者和 62 名匹配的对照者。我们使用一般线性模型分析评估了每个杏仁核亚区在整个大脑中的 dFC 平均强度的组间差异。
结果
MDD 患者表现出左侧 CM/SF 和脑干之间以及左侧 SF 和左侧丘脑之间正 dFC 强度降低；他们表现出左侧 CM 和右侧额上回之间负 dFC 强度降低（<0.05，经家族-wise 错误校正）。我们发现 MDD 患者的发病年龄与左侧 CM/脑干中 dFC 的正平均强度之间存在显著的正相关。
局限性
杏仁核亚区的定义基于细胞构筑学的划分，并且 fMRI 的时间分辨率较慢（重复时间=2 秒）。
结论
这些发现证实了 MDD 中杏仁核亚区的独特动态功能途径，并表明边缘皮质-纹状体-苍白球-丘脑回路在 MDD 的早期阶段起着至关重要的作用。
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