Charoenwisetsin Suwis, Jiranantarat Vorakran, Hirunyachoke Paphon, Udomkiat Pacharapol
Department of Orthopaedic Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Department of Anesthesiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
BMC Musculoskelet Disord. 2024 Aug 1;25(1):608. doi: 10.1186/s12891-024-07732-3.
To compare the postoperative pain score, opioid consumption, and blood loss in knee osteoarthritis patients who underwent unilateral primary total knee arthroplasty with and without intraoperative cold solution irrigation.
In total, 70 knee osteoarthritis patients were randomly included in the study and allocated into 2 groups. The first group was irrigated intraoperatively with a cold solution and the second group was irrigated intraoperatively with a room-temperature solution.
The cold solution group showed significantly lower pain scores (numerical rating scale, NRS) at 28 h postoperatively (p = 0.047). There were no significant differences in opioid consumption or blood loss between the groups.
Intraoperative cold solution irrigation in unilateral primary total knee arthroplasty patients may provide the benefit of early postoperative pain reduction for up to 28 h but has no effect in terms of reducing opioid consumption or blood loss.
The trial was registered in the Thai Clinical Trials Registry (TCTR) Trial registration number ID: TCTR20200706001 on 06/07/2020.
比较接受单侧初次全膝关节置换术的膝骨关节炎患者在术中使用和不使用冷溶液冲洗的情况下，术后疼痛评分、阿片类药物消耗量和失血量。
总共70例膝骨关节炎患者被随机纳入研究并分为两组。第一组在术中用冷溶液冲洗，第二组在术中用室温溶液冲洗。
冷溶液组在术后28小时的疼痛评分（数字评定量表，NRS）显著更低（p = 0.047）。两组之间的阿片类药物消耗量或失血量无显著差异。
单侧初次全膝关节置换术患者术中使用冷溶液冲洗可能在术后长达28小时内具有减轻早期疼痛的益处，但在减少阿片类药物消耗量或失血量方面没有效果。
该试验于2020年7月6日在泰国临床试验注册中心（TCTR）注册，试验注册号ID：TCTR20200706001。
