Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain.
Department of Health Sciences and Biomedicine, Faculty of Health Sciences, Universidad Loyola Andalucía, Sevilla, Spain.
Pediatr Obes. 2024 Oct;19(10):e13152. doi: 10.1111/ijpo.13152. Epub 2024 Jul 31.
We assessed the effects of a 20-week combined (aerobic and resistance) exercise training programme on the inflammatory profile of prepubertal children with overweight or obesity.
Totally 109 participants (10.1 ± 1.1 years, 41% girls) were randomly allocated to an exercise or control group. Adiponectin, C-reactive protein, epidermal growth factor, insulin-like growth factor-1, interleukin (IL)-1β, IL-6, leptin, tumour necrosis factor-α and vascular endothelial growth factor A (VEGFA) were analysed in plasma. Total white blood cell (WBC) count and immune subpopulations (eosinophils, basophils, neutrophils, lymphocytes and monocytes) were also determined.
No intervention effect was found for any of the analysed biomarkers (all p ≥ 0.05). We observed a significant sex by intervention interaction for IL-1β (p = 0.03). When stratifying the sample by sex, the exercise programme induced a significant effect on IL-1β levels (mean Z-score difference, 0.66 [95% confidence interval 0.32-1.01]) in girls, but not in boys. A lower number of girls in the exercise group showed a meaningful reduction in IL-1β (i.e., ≥0.2 standard deviations) than in the control group (15% vs. 85%, p = 0.01).
This exercise programme failed to improve the inflammatory profile in prepubertal children with overweight/obesity. Future studies should explore the effect of longer exercise interventions and in combination with diet.
我们评估了 20 周联合（有氧和阻力）运动训练方案对超重或肥胖青春期前儿童炎症特征的影响。
共有 109 名参与者（10.1±1.1 岁，41%为女孩）被随机分配到运动组或对照组。分析血浆中脂联素、C 反应蛋白、表皮生长因子、胰岛素样生长因子-1、白细胞介素（IL）-1β、IL-6、瘦素、肿瘤坏死因子-α和血管内皮生长因子 A（VEGFA）。还测定了总白细胞计数和免疫亚群（嗜酸性粒细胞、嗜碱性粒细胞、中性粒细胞、淋巴细胞和单核细胞）。
未发现任何分析生物标志物存在干预效应（所有 p≥0.05）。我们观察到 IL-1β 存在显著的性别与干预相互作用（p=0.03）。当按性别对样本进行分层时，运动方案在女孩中显著影响 IL-1β 水平（平均 Z 分数差异为 0.66[95%置信区间为 0.32-1.01]），但在男孩中没有。运动组中 IL-1β 有意义降低（即≥0.2 个标准差）的女孩人数低于对照组（15%比 85%，p=0.01）。
该运动方案未能改善超重/肥胖青春期前儿童的炎症特征。未来的研究应探讨更长时间的运动干预以及与饮食相结合的效果。
