Alimohammadi-Kamalabadi Malek, Ziaei Somayeh, Hasani Motahareh, Mohammadi Shooka, Mehrbod Milad, Morvaridi Mehrnaz, Persad Emma, Belančić Andrej, Malekahmadi Mahsa, Estêvão Maria Dulce da Mota Antunes de Oliveira, Daneshzad Elnaz, Heshmati Javad
Department of Cellular-Molecular Nutrition, School of Nutritional Sciences and Dietetics Tehran University of Medical Sciences Tehran Iran.
ICU Department, Emam Reza Hospital Kermanshah University of Medical Sciences Kermanshah Iran.
Health Sci Rep. 2024 Jul 30;7(8):e2276. doi: 10.1002/hsr2.2276. eCollection 2024 Aug.
Vitamin D deficiency impacts a significant proportion of the world's population, and this deficiency has been linked to various conditions characterized by imbalanced serotonin regulation. The objective of this systematic review and meta-analysis was to evaluate the effect of vitamin D supplementation on serum serotonin levels.
We conducted a comprehensive search of PubMed, Scopus, Cochrane Central for Randomized Clinical Trials, and Web of Science up to September 2022, without any language restrictions. The effect sizes were calculated using the standard mean difference (SMD) and 95% confidence interval (CI).
Six randomized clinical trials involving 356 participants were included in the analysis. Our findings indicated no significant changes in serotonin levels between the intervention and control groups (SMD: 0.24 ng/mL, 95% CI: -0.28, 0.75, > 0.10). Subgroup analysis also did not reveal any significant changes in serotonin levels among children, participants with autism spectrum disorders, interventions lasting 10 weeks or longer, or those receiving vitamin D doses below 4000 IU/day.
Although the results obtained in this systematic review are inconclusive, they support the need for further well-designed randomized trials to assess the potential role of vitamin D supplementation in regulating serotonin levels and potentially ameliorating depression and related disorders.
维生素D缺乏影响着世界上很大一部分人口，这种缺乏与多种以血清素调节失衡为特征的疾病有关。本系统评价和荟萃分析的目的是评估补充维生素D对血清素水平的影响。
我们对截至2022年9月的PubMed、Scopus、Cochrane随机临床试验中心和科学网进行了全面检索，没有任何语言限制。效应量采用标准平均差（SMD）和95%置信区间（CI）计算。
分析纳入了6项涉及356名参与者的随机临床试验。我们的研究结果表明，干预组和对照组之间血清素水平没有显著变化（SMD：0.24 ng/mL，95%CI：-0.28，0.75，>0.10）。亚组分析也未发现儿童、自闭症谱系障碍参与者、持续10周或更长时间的干预措施，或每天接受低于4000 IU维生素D剂量的参与者血清素水平有任何显著变化。
尽管本系统评价所得结果尚无定论，但它们支持需要进一步开展设计良好的随机试验，以评估补充维生素D在调节血清素水平以及潜在改善抑郁症和相关疾病方面的潜在作用。
