Department of Endocrinology, Ningbo Yinzhou No. 2 Hospital, Ningbo, China.
The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China.
Front Public Health. 2022 Aug 1;10:903547. doi: 10.3389/fpubh.2022.903547. eCollection 2022.
There have been several controversies about the correlation between vitamin D and depression. This study aimed to investigate the relationship between vitamin D supplementation and the incidence and prognosis of depression and to analyze the latent effects of subgroups including population and supplement strategy.
A systematic search for articles before July 2021 in databases (PubMed, EMBASE, Web of Science, and the Cochrane Library) was conducted to investigate the effect of vitamin D supplementation on the incidence and prognosis of depression.
This meta-analysis included 29 studies with 4,504 participants, indicating that the use of vitamin D was beneficial to a decline in the incidence of depression (SMD: -0.23) and improvement of depression treatment (SMD: -0.92). Subgroup analysis revealed that people with low vitamin D levels (<50 nmol/L) and females could notably benefit from vitamin D in both prevention and treatment of depression. The effects of vitamin D with a daily supplementary dose of >2,800 IU and intervention duration of ≥8 weeks were considered significant in both prevention and treatment analyses. Intervention duration ≤8 weeks was recognized as effective in the treatment group.
Our results demonstrate that vitamin D has a beneficial impact on both the incidence and the prognosis of depression. Whether suffering from depression or not, individuals with low vitamin D levels, dose >2,800 IU, intervention duration ≥8 weeks, and all females are most likely to benefit from vitamin D supplementation.
关于维生素 D 与抑郁症之间的相关性存在一些争议。本研究旨在探讨维生素 D 补充与抑郁症的发生和预后之间的关系，并分析包括人群和补充策略在内的亚组的潜在影响。
系统检索了 2021 年 7 月之前在数据库（PubMed、EMBASE、Web of Science 和 Cochrane Library）中发表的文章，以调查维生素 D 补充对抑郁症发生和预后的影响。
本荟萃分析纳入了 29 项研究，共 4504 名参与者，结果表明使用维生素 D 有利于降低抑郁症的发生率（SMD：-0.23）和改善抑郁症的治疗效果（SMD：-0.92）。亚组分析显示，维生素 D 水平较低（<50 nmol/L）的人群和女性在预防和治疗抑郁症方面均能明显受益于维生素 D。每日补充剂量>2800 IU 和干预持续时间≥8 周的维生素 D 效果在预防和治疗分析中均被认为是显著的。干预持续时间≤8 周被认为在治疗组中有效。
我们的结果表明维生素 D 对抑郁症的发生和预后均有有益影响。无论是否患有抑郁症，维生素 D 水平较低、剂量>2800 IU、干预持续时间≥8 周以及所有女性最有可能从维生素 D 补充中获益。
