Di Rosa Claudia, Van den Houte Karen, Altomare Annamaria, Guarino Michele Pier Luca, Besard Linde, Arts Joris, Caenepeel Philip, Piessevaux Hubert, Vandenberghe Alain, Matthys Cristophe, Biesiekierski Jessica R, Capiau Luc, Ceulemans Steven, Gernay Olivier, Jones Lydia, Maes Sophie, Peetermans Christian, Raat Willem, Stubbe Jeroen, Van Boxstael Rudy, Vandeput Olivia, Van Steenbergen Sophie, Van Oudenhove Lukas, Vanuytsel Tim, Jones Mike, Tack Jan, Carbone Florencia
Campus Bio-Medico University, Roma, Italy.
Translational Research Center for Gastrointestinal Diseases (TARGID), Department of Chronic Diseases and Metabolism (ChroMeta), University of Leuven, Leuven, Belgium.
Therap Adv Gastroenterol. 2024 Jul 30;17:17562848241255296. doi: 10.1177/17562848241255296. eCollection 2024.
Irritable bowel syndrome (IBS) is a disorder of gut-brain interaction characterized by recurrent abdominal pain related to defecation and/or associated to a change in bowel habits. According to the stool type, four different IBS subtypes can be recognized, constipation predominant (IBS-C), diarrhea predominant (IBS-D), mixed (IBS-M), and undefined (IBS-U). Patients report that their IBS symptoms are exacerbated by food. Thus, it is important to find a nutritional approach that could be effective in reducing IBS symptoms.
The present work is a analysis of the previously published DOMINO trial. It aimed to evaluate the effects of a self-instructed FODMAP-lowering diet smartphone application on symptoms and psychosocial aspects in primary care IBS stratifying the results for each IBS subtypes.
analysis.
Two hundred twenty-two primary care IBS patients followed a FODMAP-lowering diet for 8 weeks with the support of a smartphone application. Two follow-up visits were scheduled after 16 and 24 weeks. IBS-Symptoms Severity Score (IBS-SSS), quality of life (QoL), and adherence and dietary satisfaction were evaluated.
After 8 weeks, IBS-SSS improved in all IBS subtypes ( < 0.0001). Physician Health Questiionnaire (PHQ-15) improved only in IBS-D ( = 0.0006), whereas QoL improved both in IBS-D ( = 0.01) and IBS-M ( = 0.005).
This analysis showed that the app is useful in all IBS subtypes; thus, it could be used as an effective tool by both general practitioners and patients to manage symptoms in primary care.
Ethical Commission University Hospital of Leuven reference number: S59482. Clinicaltrial.gov reference number: NCT04270487.
肠易激综合征（IBS）是一种肠-脑相互作用的紊乱疾病，其特征为与排便相关的反复腹痛和/或伴有排便习惯改变。根据粪便类型，可识别出四种不同的IBS亚型，即便秘型（IBS-C）、腹泻型（IBS-D）、混合型（IBS-M）和未定型（IBS-U）。患者报告称，他们的IBS症状会因食物而加重。因此，找到一种能有效减轻IBS症状的营养方法很重要。
本研究是对先前发表的DOMINO试验的分析。其旨在评估一款自我指导的降低可发酵寡糖、双糖、单糖和多元醇（FODMAP）饮食的智能手机应用程序对初级保健中IBS患者症状及心理社会方面的影响，并对每种IBS亚型的结果进行分层分析。
分析。
222名初级保健IBS患者在一款智能手机应用程序的支持下遵循降低FODMAP饮食8周。在16周和24周后安排了两次随访。评估了IBS症状严重程度评分（IBS-SSS）、生活质量（QoL）、依从性和饮食满意度。
8周后，所有IBS亚型的IBS-SSS均有所改善（<0.0001）。医生健康问卷（PHQ-15）仅在IBS-D亚型中有所改善（=0.0006），而QoL在IBS-D（=0.01）和IBS-M（=0.005）中均有所改善。
该分析表明该应用程序对所有IBS亚型均有用；因此，它可被全科医生和患者用作在初级保健中管理症状的有效工具。
鲁汶大学医院伦理委员会参考编号：S59482。Clinicaltrial.gov参考编号：NCT04270487。
