Hu Qi, Chen Xiao-Pin, Tang Zhi-Jun, Zhu Xue-Yuan, Liu Chun
College of Integrated Traditional Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha 410208, Hunan Province, China.
Department of Anorectal Surgery, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu Province, China.
World J Gastrointest Surg. 2024 Jul 27;16(7):2183-2193. doi: 10.4240/wjgs.v16.i7.2183.
According to the theory of traditional Chinese medicine (TCM), the spleen and stomach are the basis of acquired nature and the source of qi and blood biochemistry. After surgery and chemotherapy, patients with colorectal cancer often develop spleen and stomach qi deficiency syndrome, leading to decreased immune function. Buzhong Yiqi decoction, a classic TCM prescription, has the effect of tonifying middle-jiao and invigorating qi, boosting Yang, and suppressing immune-related inflammation. Moreover, it is widely used in the treatment of spleen and stomach qi deficiency syndrome.
To investigate the effect of Buzhong Yiqi decoction on spleen and stomach qi deficiency in patients with colorectal cancer.
One hundred patients with colorectal cancer who underwent preoperative chemotherapy and laparoscopy at The First TCM Hospital of Changde from January 2022 to October 2023 were retrospectively analyzed. The patients were divided equally into control and observation groups. Both groups underwent conventional rehabilitation surgery, and the observation group was supplemented with Buzhong Yiqi decoction. SPSS 26.0 was used for statistical analyses. The test was used for univariate analysis; independent sample -tests were used in all cases.
No significant differences were observed preoperatively in the general characteristics of the two groups. Fourteen days post-surgery, the abdominal distension, emaciation, loose stool, loss of appetite, and vomiting scores were significantly lower in the observation group than in the control group ( < 0.05). Immune function and interleukin (IL)-10 levels in the observation group were significantly higher than those of the control group, whereas IL-6, tumor necrosis factor-α, and C-reactive protein levels, tumor biological indexes, and adverse reactions in the observation group were significantly lower than those of the control group ( < 0.05). One month after surgery, the patients' quality of life in the observation group was significantly higher than that of the patients in the control group ( < 0.05).
Buzhong Yiqi decoction can regulate inflammatory responses and metabolic processes by enhancing immune function, thereby promoting overall immune nutrition and restoring the body's balance.
根据中医理论，脾胃是后天之本，气血生化之源。结直肠癌患者术后及化疗后常出现脾胃气虚证，导致免疫功能下降。补中益气汤是经典的中医方剂，具有补中益气、升阳举陷、抑制免疫相关炎症的作用。此外，它还广泛用于治疗脾胃气虚证。
探讨补中益气汤对结直肠癌患者脾胃气虚的影响。
回顾性分析2022年1月至2023年10月在常德市第一中医医院接受术前化疗和腹腔镜手术的100例结直肠癌患者。将患者平均分为对照组和观察组。两组均接受常规康复手术，观察组加用补中益气汤。采用SPSS 26.0进行统计分析。采用检验进行单因素分析；所有病例均采用独立样本检验。
两组术前一般特征无显著差异。术后14天，观察组腹胀、消瘦、大便溏薄、食欲不振和呕吐评分均显著低于对照组（<0.05）。观察组免疫功能和白细胞介素（IL）-10水平显著高于对照组，而观察组IL-6、肿瘤坏死因子-α、C反应蛋白水平、肿瘤生物学指标和不良反应显著低于对照组（<0.05）。术后1个月，观察组患者生活质量显著高于对照组（<0.05）。
补中益气汤可通过增强免疫功能调节炎症反应和代谢过程，从而促进整体免疫营养，恢复机体平衡。
