Zhou Feifei, Chen Chen, Shi Jiani, Zhou Qianru, Jin Lijun, Ma Xiaofang
Department of Traditional Chinese Medicine, Center for Reproductive Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, China.
Front Surg. 2022 Apr 13;9:882621. doi: 10.3389/fsurg.2022.882621. eCollection 2022.
To study the clinical application value of Modified Buzhong Yiqi Decoction in the treatment of female stress urinary incontinence (SUI).
A total of 103 female patients with SUI were included in this study, 13 were lost to follow-up, and the final number of studies was 90. General information about the patients, including age, years of menopause, body mass index (BMI), reproductive history, chronic respiratory disease, hypertension, and diabetes, were recorded. All the patients were treated with Modified Buzhong Yiqi Decoction alone for 4 weeks. The Patient Global Impression of Improvement (PGI-I), the International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form (ICI-QSF) and 72-h voiding diary were used to evaluate the patients' subjective symptoms and urinary incontinence degree before treatment, 1 month after treatment and 1 year after treatment, the efficacy and efficacy-related factors of Modified Buzhong Yiqi Decoction in the treatment of female SUI were analyzed.
One month after Modified Buzhong Yiqi Decoction treatment, compared with before treatment, the PGI-I questionnaire was very much better (68.89%), much better (8.89%), a little better (12.33%), no change (8.89%), the ICI-QSF score decreased ( < 0.05), and 72-h urine leakage frequency decreased ( < 0.05); One year after treatment compared with before treatment, the PGI-I questionnaire was very much better (40.00%), much better (17.78%), a little better (12.22%), no change (30.00%), the ICI-QSF score decreased ( < 0.05), and 72-h urine leakage frequency decreased ( < 0.05); and 1 year after treatment compared with 1 month after treatment, the ratio of very much better at 1 year after treatment was significantly decreased ( < 0.05), the score of the ICI-QSF was significantly increased ( < 0.05), and 72-h urine leakage frequency was significantly increased ( < 0.05). The correlation analysis showed that the efficacy at 1 month after treatment was negatively correlated with the severity of SUI and chronic respiratory diseases, but was not significantly correlated with age, menopause status, BMI, number of pregnancies, and number of births. The efficacy at 1 year after treatment was negatively correlated with the severity of SUI, chronic respiratory disease, age, and number of births and was positively correlated with BMI, but not significantly correlated with menopause status and number of pregnancies.
Modified Buzhong Yiqi Decoction can effectively treat SUI in women. The efficacy is related to the severity of SUI and chronic abdominal hypertension, but the long-term efficacy decreases.
探讨加味补中益气汤治疗女性压力性尿失禁（SUI）的临床应用价值。
本研究共纳入103例女性SUI患者，失访13例，最终纳入研究90例。记录患者的一般资料，包括年龄、绝经年限、体重指数（BMI）、生育史、慢性呼吸系统疾病、高血压及糖尿病等。所有患者单纯服用加味补中益气汤治疗4周。采用患者总体印象改善量表（PGI-I）、国际尿失禁咨询委员会尿失禁简表（ICI-QSF）及72小时排尿日记，分别于治疗前及治疗后1个月、1年评估患者主观症状及尿失禁程度，分析加味补中益气汤治疗女性SUI的疗效及疗效相关因素。
加味补中益气汤治疗1个月后，与治疗前比较，PGI-I问卷显示非常好（68.89%）、好多了（8.89%）、稍好（12.33%）、无变化（8.89%），ICI-QSF评分降低（P<0.05），72小时漏尿次数减少（P<0.05）；治疗1年后与治疗前比较，PGI-I问卷显示非常好（40.00%）、好多了（17.78%）、稍好（12.22%）、无变化（30.00%），ICI-QSF评分降低（P<0.05），72小时漏尿次数减少（P<0.05）；治疗后1年与治疗后1个月比较，治疗后1年非常好的比例显著降低（P<0.05），ICI-QSF评分显著升高（P<0.05），72小时漏尿次数显著增加（P<0.05）。相关性分析显示，治疗后1个月疗效与SUI严重程度及慢性呼吸系统疾病呈负相关，与年龄、绝经状态、BMI、妊娠次数及分娩次数无显著相关性；治疗后1年疗效与SUI严重程度、慢性呼吸系统疾病、年龄及分娩次数呈负相关，与BMI呈正相关，与绝经状态及妊娠次数无显著相关性。
加味补中益气汤可有效治疗女性SUI，疗效与SUI严重程度及慢性腹压增高有关，但远期疗效降低。
