Inada Yuta, Sakurada Yoichi, Shijo Taiyo, Kikushima Wataru, Kashiwagi Kenji
Department of Ophthalmology, University of Yamanashi, Chuo, JPN.
Cureus. 2024 Jul 1;16(7):e63557. doi: 10.7759/cureus.63557. eCollection 2024 Jul.
We report the familial occurrence of a severe phenotype of central serous chorioretinopathy (CSC). A 62-year-old man was referred to our institute to treat a macular lesion in his right eye. Best-corrected visual acuity (BCVA) in his right eye was 0.05 (decimal format). On the initial visit, swept-source optical coherence tomography (SS-OCT) demonstrated subretinal hyperreflective material (SHRM) and subretinal fluid involving the central macula in the right eye and a descending tract on fundus autofluorescence (FAF) in the left eye, and fluorescein angiography revealed focal leakage corresponding to choroidal vascular hyperpermeability (CVH) on indocyanine green angiography (ICGA) of the right eye. He received photodynamic therapy (PDT) for the right eye and exudation disappeared. His 66-year-old elder brother had a medical history of CSC in both eyes and had received treatment at our hospital at 61 years old. On the initial presentation, ICGA showed multiple CVH in both eyes, and FAF showed hypofluorescence corresponding to retinal pigment epithelium (RPE) tears and RPE atrophy in both eyes. Bullous retinal detachment (RD) developed inferiorly in both eyes, and a vitrectomy was performed for the right eye to repair RD. The baseline BCVA was 0.3 in both eyes. Two years after the initial visit, recurrent serous RD developed in his left eye, and multiple PDT sessions were performed during the six-year follow-up. A severe phenotype of CSC may be associated with a genetic background.
我们报告了一例家族性中心性浆液性脉络膜视网膜病变（CSC）的严重表型。一名62岁男性因右眼黄斑病变转诊至我院。其右眼最佳矫正视力（BCVA）为0.05（十进制）。初诊时，扫频光学相干断层扫描（SS - OCT）显示右眼黄斑中心凹处有视网膜下高反射物质（SHRM）和视网膜下液，左眼眼底自发荧光（FAF）有一条下行带，荧光素血管造影显示右眼吲哚菁绿血管造影（ICGA）上与脉络膜血管高通透性（CVH）对应的局灶性渗漏。他接受了右眼光动力疗法（PDT），渗出消失。他66岁的哥哥有双眼CSC病史，61岁时在我院接受过治疗。初诊时，ICGA显示双眼有多处CVH，FAF显示双眼与视网膜色素上皮（RPE）撕裂和RPE萎缩对应的低荧光。双眼下方均发生了大泡性视网膜脱离（RD），右眼进行了玻璃体切除术以修复RD。双眼基线BCVA均为0.3。初诊两年后，其左眼发生复发性浆液性RD，在六年随访期间进行了多次PDT治疗。CSC的严重表型可能与遗传背景有关。
