Tomimasu K, Hayashi K, Tsuji Y
Jpn J Antibiot. 1985 Oct;38(10):3065-9.
Ceftizoxime suppository (CZX-S) was given to 6 patients, with the following results. The peak serum concentration of CZX was 1.8-7.5 micrograms/ml at 30 minutes after dosing of CZX-S with 9.6-16.7 mg/kg. The antibacterial activity of CZX revealed that the drug can be expected to be effective sufficiently. The overall effect of CZX-S was "markedly improved" in 1 and "moderately improved" in 3 of the 4 patients with pneumonia and "markedly improved" in 1 and "slightly improved" in 1 of the 2 with UTI. CZX-S caused a slight increase in frequency of defecation in 2 of the 6 patients. There were no abnormal findings of symptoms or laboratory test values which were ascribable to side effects.
给6例患者使用了头孢唑肟栓剂（CZX - S），结果如下。在以9.6 - 16.7mg/kg剂量给予CZX - S后30分钟，CZX的血清峰值浓度为1.8 - 7.5微克/毫升。CZX的抗菌活性表明该药物有望充分发挥疗效。在4例肺炎患者中，CZX - S的总体效果为1例“显著改善”，3例“中度改善”；在2例尿路感染患者中，1例“显著改善”，1例“轻度改善”。6例患者中有2例排便频率略有增加。未发现可归因于副作用的症状或实验室检查值异常。
