Liu Jing, Wang Lu-Yi, Liu Zi-Bo, Li Hong-Ling, Chen Yu-Yan, Yuan Xiao-Kai, Chi Lin
Second Department of Rehabilitation, Second Hospital of Hebei Medical University, NO.215 Heping West Road, Xinhua District, Shijiazhuang, 050000, China.
China Aerospace Science & Industry Corporation 731 Hospital, NO.3 Zhen Gang Nan Li, Yun Gang, Feng Tai District, Beijing, 100074, China.
Neurol Sci. 2025 Jan;46(1):257-266. doi: 10.1007/s10072-024-07704-4. Epub 2024 Aug 1.
To investigate the efficacy of transcranial ultrasound stimulation (TUS) combined with Fastigial nucleus stimulation (FNS) on cerebral blood flow and limb function in patients in the acute phase of ischemic stroke.
A total of 90 patients in the acute phase of ischemic stroke were randomly divided into an FNS, TUS, and TUS + FNS group (30 patients each), and all patients also received conventional treatment. The FNS group was treated with FNS alone. The TUS group was treated with TUS alone. The TUS + FNS group was treated with both TUS and FNS. The three groups were treated once a day for 6 days a week.
The simplified Fugl-Meyer Assessment (FMA) and Barthel index scores (BI), and the peak systolic blood flow velocity (Vs) and the mean blood flow velocity (Vm) of the anterior cerebral artery, middle cerebral artery, and posterior cerebral artery, were significantly higher in all three groups compared with before treatment (P < 0.05). The scores for the TUS group were higher than for the FNS group (P < 0.05), and the scores of the TUS + FNS group were higher than the TUS and FNS groups, respectively (P < 0.05). The total effective rate was 63.3%, 70.0%, and 90.0% in the FNS, TUS, and TUS + FNS groups, respectively, and the difference between the three groups was statistically significant (P < 0.05).
The FNS and TUS treatments improved the function of and accelerated cerebral blood flow in patients with acute ischemic stroke to different degrees, and the combined use of both treatment types was overall more effective.
探讨经颅超声刺激（TUS）联合小脑顶核刺激（FNS）对缺血性脑卒中急性期患者脑血流及肢体功能的影响。
将90例缺血性脑卒中急性期患者随机分为FNS组、TUS组和TUS+FNS组，每组30例，所有患者均接受常规治疗。FNS组单纯采用FNS治疗；TUS组单纯采用TUS治疗；TUS+FNS组同时采用TUS和FNS治疗。三组均每日治疗1次，每周治疗6天。
三组患者治疗后的简化Fugl-Meyer评估量表（FMA）评分、Barthel指数（BI）评分，以及大脑前动脉、大脑中动脉和大脑后动脉的收缩期峰值血流速度（Vs）和平均血流速度（Vm）均较治疗前显著升高（P<0.05）。TUS组的评分高于FNS组（P<0.05），TUS+FNS组的评分分别高于TUS组和FNS组（P<0.05）。FNS组、TUS组和TUS+FNS组的总有效率分别为63.3%、70.0%和90.0%，三组间差异有统计学意义（P<0.05）。
FNS和TUS治疗均能不同程度地改善急性缺血性脑卒中患者的功能并促进脑血流，两者联合应用总体效果更佳。
