Guo Jiecheng, Lo Wai Leung Ambrose, Hu Huijing, Yan Li, Li Le
Institute of Medical Research, Northwestern Polytechnical University, Xi'an, China.
Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Front Neurosci. 2022 Jul 22;16:964060. doi: 10.3389/fnins.2022.964060. eCollection 2022.
Ischemic stroke is a serious medical condition that is caused by cerebral vascular occlusion and leads to neurological dysfunction. After stroke, patients suffer from long-term sensory, motor and cognitive impairment. Non-invasive neuromodulation technology has been widely studied in the field of stroke rehabilitation. Transcranial ultrasound stimulation (TUS), as a safe and non-invasive technique with deep penetration ability and a tiny focus, is an emerging technology. It can produce mechanical and thermal effects by delivering sound waves to brain tissue that can induce the production of neurotrophic factors (NFs) in the brain, and reduce cell apoptosis and the inflammatory response. TUS, which involves application of an acoustic wave, can also dissolve blood clots and be used to deliver therapeutic drugs to the ischemic region. TUS has great potential in the treatment of ischemic stroke. Future advancements in imaging and parameter optimization will improve the safety and efficacy of this technology in the treatment of ischemic stroke.
缺血性中风是一种由脑血管闭塞引起并导致神经功能障碍的严重病症。中风后，患者会遭受长期的感觉、运动和认知障碍。非侵入性神经调节技术在中风康复领域已得到广泛研究。经颅超声刺激（TUS）作为一种具有深度穿透能力和微小焦点的安全无创技术，是一项新兴技术。它通过向脑组织传递声波产生机械和热效应，可诱导大脑中神经营养因子（NFs）的产生，并减少细胞凋亡和炎症反应。涉及声波应用的TUS还可以溶解血栓，并用于将治疗药物输送到缺血区域。TUS在缺血性中风的治疗中具有巨大潜力。成像和参数优化方面的未来进展将提高该技术在缺血性中风治疗中的安全性和有效性。
