Ioachimescu Octavian C, Stoller James K
Professor of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine and Clinical and Translational Science Institute, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America.
Adjunct Professor of Medicine, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, School of Medicine, Emory University, Atlanta, Georgia, United States of America.
PLoS One. 2024 Aug 1;19(8):e0307966. doi: 10.1371/journal.pone.0307966. eCollection 2024.
Area under expiratory flow-volume curve (AEX) has been shown to be a valuable functional measurement in respiratory physiology. Area under inspiratory flow-volume loop (AIN) also shows promise in characterizing upper and/or lower airflow obstruction.
we aimed here to develop normative reference values for AIN, able to ascertain deviations from normal.
We analyzed AIN in 4,980 spirometry tests recorded in non-smoking, healthy individuals in the Pulmonary Function Testing Laboratory.
The mean (95% confidence interval, CI), standard deviation and median (25th-75th interquartile range) AIN were 16.05 (15.79-16.31), 9.08 and 14.72 (9.12-21.42) L2·sec-1, respectively. The mean (95% CI) and standard deviation of the best-trial measurements for square root of AIN (Sqrt AIN) were 3.84 (3.81-3.87) and 1.14; 4.15 (4.12-4.18) and 1.03 in men, and 2.68 (2.63-2.72) and 0.72 L·sec-1/2 in women. The mean (standard deviation) of pre- and post-bronchodilator Sqrt AIN were 3.71 (1.17) and 3.81 (1.19) L·sec-1/2, respectively. The mean (95% CI), standard deviation and lowest 5th percentile (lower limit of normal, LLN) of Sqrt AIN/Sqrt AEX (%) were 101.3 (100.82-101.88), 18.7, and 71.8%; stratified by gender, it was 102.2 (101.6-102.8), 18.6, and 72.8% in men, and 98 (96.9-99.2), 18.8, and 68.6% in women, respectively.
The availability of area under the inspiratory flow-volume curve (AIN) and the derived indices offers a promising opportunity to assess upper airway disease (e.g., involvement of larynx, trachea or major bronchi), especially because some of these measurements appear to be independent of age, race, height, and weight.
呼气流量-容积曲线下面积（AEX）已被证明是呼吸生理学中一项有价值的功能测量指标。吸气流量-容积环下面积（AIN）在表征上呼吸道和/或下呼吸道气流阻塞方面也显示出前景。
我们旨在制定AIN的正常参考值，以确定与正常情况的偏差。
我们分析了肺功能检测实验室中4980例非吸烟健康个体的肺活量测定测试中的AIN。
AIN的平均值（95%置信区间，CI）、标准差和中位数（第25-75百分位数范围）分别为16.05（15.79-16.31）、9.08和14.72（9.12-21.42）L2·秒-1。AIN平方根（Sqrt AIN）最佳试验测量值的平均值（95%CI）和标准差在男性中分别为3.84（3.81-3.87）和1.14；4.15（4.12-4.18）和1.03，在女性中分别为2.68（2.63-2.72）和0.72L·秒-1/2。支气管扩张剂使用前和使用后Sqrt AIN的平均值（标准差）分别为3.71（1.17）和3.81（1.19）L·秒-1/2。Sqrt AIN/Sqrt AEX（%）的平均值（95%CI）、标准差和第5百分位数下限（正常下限，LLN）分别为101.3（100.82-101.88）、18.7和71.8%；按性别分层，男性分别为102.2（101.6-102.8）、18.6和72.8%，女性分别为98（96.9-99.2）、18.8和68.6-%。
吸气流量-容积曲线下面积（AIN）及其衍生指标的可用性为评估上气道疾病（如喉、气管或主支气管受累）提供了一个有前景的机会，特别是因为其中一些测量值似乎与年龄、种族、身高和体重无关。
