Roland Caroline Borup, Seyedhosseini Parisa, Knudsen Signe de Place, Jessen Anne Dsane, Jensen Ida Karoline Bach, Bendix Jane M, van Hall Gerrit, Molsted Stig, Alomairah Saud Abdulaziz, Løkkegaard Ellen, Stallknecht Bente, Clausen Tine D
Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Department of Gynaecology and Obstetrics, Copenhagen University Hospital-North Zealand, Hilleroed, Denmark.
PLoS One. 2024 Aug 1;19(8):e0308214. doi: 10.1371/journal.pone.0308214. eCollection 2024.
The main objective of the study was to investigate the effects of prenatal exercise interventions on maternal body composition at 28 weeks gestation and 7-14 days after delivery. We also explored associations between physical activity (PA) per se and body composition. This study presents secondary outcomes of the FitMum randomized controlled trial, which included healthy inactive pregnant women at gestational age ≤ 15+0 weeks. They were randomized to structured supervised exercise training, motivational counselling on PA, or standard care. Maternal body composition was measured by doubly labeled water at 28 weeks gestation (n = 134) and by dual-energy X-ray absorptiometry scan 7-14 days after delivery (n = 117). PA, including moderate-to-vigorous-intensity PA (MVPA), active kilocalories, and steps, were measured continuously from inclusion to delivery by a wrist-worn activity tracker. One hundred fifty pregnant women were included with a median pre-pregnancy body mass index (BMI) of 24.1 (21.6-27.9) kg/m2. We found no differences between groups in fat mass, fat percentage or fat-free mass at 28 weeks gestation or 7-14 days after delivery. Visceral adipose tissue mass and bone mineral density measured 7-14 days after delivery did not differ between groups either. Linear regression analyses adjusted for pre-pregnancy BMI showed that a higher number of daily steps was associated with lower fat mass, fat percentage, and visceral adipose tissue mass at 28 weeks gestation and 7-14 days after delivery. Active kilocalories during pregnancy was positively associated with fat-free mass 7-14 days after delivery. Neither structured supervised exercise training nor motivational counselling on PA during pregnancy affected maternal body composition at 28 weeks gestation or 7-14 days after delivery compared to standard care. Interestingly, when adjusted for pre-pregnancy BMI, higher number of daily steps was associated with lower fat content during pregnancy and after delivery, whereas MVPA and active kilocalories were not. Trial registration: ClinicalTrials.gov; NCT03679130; 20/09/2018.
该研究的主要目的是调查孕期运动干预对妊娠28周时以及产后7 - 14天产妇身体成分的影响。我们还探讨了体育活动（PA）本身与身体成分之间的关联。本研究展示了FitMum随机对照试验的次要结果，该试验纳入了妊娠≤15 + 0周的健康非运动型孕妇。她们被随机分为结构化监督运动训练组、PA激励咨询组或标准护理组。在妊娠28周时（n = 134）通过双标水法测量产妇身体成分，在产后7 - 14天（n = 117）通过双能X线吸收法扫描测量。从纳入研究到分娩期间，通过佩戴在手腕上的活动追踪器连续测量PA，包括中等到高强度PA（MVPA）、活动千卡数和步数。纳入了150名孕妇，孕前体重指数（BMI）中位数为24.1（21.6 - 27.9）kg/m²。我们发现在妊娠28周时或产后7 - 14天，各组之间在脂肪量、脂肪百分比或去脂体重方面没有差异。产后7 - 14天测量的内脏脂肪组织量和骨矿物质密度在各组之间也没有差异。对孕前BMI进行调整后的线性回归分析表明，在妊娠28周时以及产后7 - 14天，每天步数较多与较低的脂肪量、脂肪百分比和内脏脂肪组织量相关。孕期的活动千卡数与产后7 - 14天的去脂体重呈正相关。与标准护理相比，孕期的结构化监督运动训练或PA激励咨询在妊娠28周时或产后7 - 14天均未影响产妇身体成分。有趣的是，在对孕前BMI进行调整后，孕期和产后每天步数较多与较低的脂肪含量相关，而MVPA和活动千卡数则不然。试验注册：ClinicalTrials.gov；NCT03679130；2018年9月20日。
