Department of Plastic and Aesthetic Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China.
Comput Biol Med. 2024 Sep;180:108867. doi: 10.1016/j.compbiomed.2024.108867. Epub 2024 Jul 31.
Non-coding RNAs (ncRNAs), as key regulators involving in intercellular biological processes, are more prominent in many malignancies, especially for hepatocellular carcinoma (HCC). Herein, we conduct a comprehensive review to summarize diverse ncRNAs roles in HCC metastatic mechanism. We focus on four signaling pathways that predominate in HCC metastatic process, including Wnt/β-catenin, HIF-1α, IL-6, and TGF-β pathways. MicroRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) employed different mechanisms to participate in the regulation of the key genes in these pathways, typical as interaction with DNA to control transcription, with RNA to control translation, and with protein to control stability. Therefore, ncRNAs may become potential biomarkers and therapeutic targets for HCC metastasis.
非编码 RNA（ncRNAs）作为参与细胞间生物过程的关键调节剂，在许多恶性肿瘤中更为突出，尤其是在肝细胞癌（HCC）中。在此，我们进行了全面的综述，以总结不同的 ncRNAs 在 HCC 转移机制中的作用。我们重点关注在 HCC 转移过程中占主导地位的四个信号通路，包括 Wnt/β-catenin、HIF-1α、IL-6 和 TGF-β 通路。miRNAs、lncRNAs 和 circRNAs 采用不同的机制参与这些通路中关键基因的调控，典型的机制包括与 DNA 相互作用以控制转录、与 RNA 相互作用以控制翻译以及与蛋白质相互作用以控制稳定性。因此，ncRNAs 可能成为 HCC 转移的潜在生物标志物和治疗靶点。
