Department of Chemistry, Higher Teacher Training College, University of Yaoundé I, P.O. Box 47, Yaoundé, Cameroon; Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon.
Department of Chemistry, Higher Teacher Training College, University of Yaoundé I, P.O. Box 47, Yaoundé, Cameroon; Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon.
Fitoterapia. 2024 Oct;178:106154. doi: 10.1016/j.fitote.2024.106154. Epub 2024 Jul 30.
Besides plants and animals, the fungal kingdom consists of several species characterized by various forms and applications. Fungi are amazing producers of bioactive natural products with applications in medicine and agriculture. Though this kingdom has been extensively investigated worldwide, it remains relatively underexplored in Africa. To address the knowledge gaps, encourage research interest, and suggest opportunities for the discovery of more bioactive substances from African fungi, we considered it appropriate to extensively review the research work carried out on African fungi since 1988. This review summarizes the diversity and distribution of fungi throughout Africa, the secondary metabolites yet reported from studied fungi, their biological activities and, the countries where they were collected. The studied fungi originated from eleven African countries and were mainly endophytic fungi and higher fungi (macrofungi). Their investigation led to the isolation of five hundred and three (503) compounds with polyketides representing the main class of secondary metabolites. The compounds exhibited varied biological activities with antibacterial and antiproliferative properties being the most prominent.
除了植物和动物，真菌界还包括多种以不同形态和应用为特征的物种。真菌是具有医学和农业应用的生物活性天然产物的惊人生产者。尽管这个领域在全球范围内得到了广泛的研究，但在非洲相对较少被探索。为了填补知识空白，鼓励研究兴趣，并为发现更多来自非洲真菌的生物活性物质提供机会，我们认为广泛回顾自 1988 年以来在非洲真菌方面开展的研究工作是合适的。本综述总结了真菌在整个非洲的多样性和分布、从研究真菌中分离出来的次生代谢产物、它们的生物活性以及它们的采集国家。研究真菌来自 11 个非洲国家，主要是内生真菌和高等真菌（大型真菌）。对它们的研究导致了 503 种化合物的分离，其中聚酮类化合物代表了主要的次生代谢产物类别。这些化合物表现出多种生物活性，其中抗菌和抗增殖活性最为突出。
