海洋小单孢菌的次生代谢产物：化学与生物活性。

Secondary Metabolites from Marine Micromonospora: Chemistry and Bioactivities.

机构信息

School of Resource and Environmental and Chemical Engineering, Nanchang University, 999 Xuefu Ave., Nanchang, 330031, P. R. China.

State Key Laboratory of Dairy Biotechnology, Technology Center and Dairy Research Institute of Bright Dairy and Food Co., Ltd., 1518 West Jiangchang Road, Shanghai, 200436, P. R. China.

出版信息

Chem Biodivers. 2020 Apr;17(4):e2000024. doi: 10.1002/cbdv.202000024. Epub 2020 Mar 18.

DOI:10.1002/cbdv.202000024

PMID:32100940

Abstract

Marine Micromonospora was revealed to be a rather untapped and a rich source of chemically diverse and unique bioactive natural products. This review is aimed to make a comprehensive survey of secondary metabolites that were derived from marine Micromonospora including chemical diversity and biological activities. A total of 116 compounds from 41 marine Micromonospora species have been reported, covering the literatures from 1997 to 2019. These compounds contain several structural classes such as polyketides (PKS), nonribosomal peptides (NRPS), PKS-NRPS hybrids, terpenes and others, and they present cytotoxic, antibacterial, antiparasitic, chemopreventive or antioxidant activities.

摘要

海洋小单孢菌被揭示为一个相当未被开发的、具有丰富的化学多样性和独特生物活性天然产物的来源。本综述旨在对来源于海洋小单孢菌的次生代谢产物进行全面调查，包括化学多样性和生物活性。从 1997 年到 2019 年的文献中，共报道了 41 种海洋小单孢菌的 116 种化合物。这些化合物包含聚酮类化合物（PKS）、非核糖体肽（NRPS）、PKS-NRPS 杂合、萜类化合物等多种结构类型，具有细胞毒性、抗菌、抗寄生虫、化学预防或抗氧化活性。