K. Callis Duffin, MD, MS, Department of Dermatology, Spencer Fox Eccles School of Medicine, University of Utah, Salt Lake City, Utah, USA.
H.B. Thio, MD, PhD, Department of Dermatology, Erasmus Medical Center, Rotterdam, the Netherlands.
J Rheumatol. 2024 Oct 1;51(Suppl 2):77-79. doi: 10.3899/jrheum.2024-0592.
Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome and chronic nonbacterial osteomyelitis (CNO) are rare autoinflammatory/autoimmune conditions seen in adults and children. Although osteoarticular manifestations are the primary distinguishing features of SAPHO, over half of patients also have palmoplantar pustulosis (PPP). These and other associated disorders such as acne, inflammatory bowel disease, and hidradenitis suppurativa are characterized, at least in the early stages, by neutrophilic infiltration. The bone and skin manifestations exhibit both innate and adaptive immune responses and therefore share similar pathogenic molecules and overlapping treatment targets. At the Group for Research and Assessment for Psoriasis and Psoriatic Arthritis (GRAPPA) 2023 annual meeting, a 3-part presentation provided an overview of current efforts at establishing consensus on diagnosis/classification, treatment, and core outcome sets for SAPHO/CNO; an overview of PPP in SAPHO and as a standalone condition; and finally, an overview of the role of the neutrophil in these disorders.
滑膜炎、痤疮、脓疱病、骨质肥厚、骨炎（SAPHO）综合征和慢性非细菌性骨髓炎（CNO）是成人和儿童中罕见的自身炎症/自身免疫性疾病。虽然骨关节炎表现是 SAPHO 的主要特征，但超过一半的患者也有掌跖脓疱病（PPP）。这些和其他相关疾病，如痤疮、炎症性肠病和化脓性汗腺炎，至少在早期阶段以中性粒细胞浸润为特征。骨骼和皮肤表现都存在先天和适应性免疫反应，因此具有相似的致病分子和重叠的治疗靶点。在 2023 年 GRAPPA 年会的 3 个部分的演讲中，概述了目前在 SAPHO/CNO 的诊断/分类、治疗和核心结局集方面建立共识的努力；概述了 SAPHO 中的 PPP 以及作为一个独立的疾病；最后，概述了中性粒细胞在这些疾病中的作用。
