Chen Xiaoli, Liu Huihong, Yue Yankun, Wang Haiwei
Department of Ophthalmology, Fu Xing Hospital, Capital Medical University, 20 Street of FuXingMenWai, XiCheng District, Beijing, 100038, China.
Int Ophthalmol. 2025 Aug 13;45(1):333. doi: 10.1007/s10792-025-03714-z.
To evaluate the clinical significance of hematological indicators and ocular parameters in patients with non-arteritic anterior ischemic optic neuropathy (NAION).
In this retrospective study, 31 NAION patients and 117 age- and gender-matched control subjects were enrolled in 2019-2024. All participants underwent a comprehensive eye examination and received a complete blood count. Hematological parameters (leukocytes, neutrophils, lymphocytes, monocytes, mean platelet volume, platelet distribution width (PDW), activated partial thromboplastin time, and international normalized ration) and ocular parameters including axial length and anterior chamber depth were collected. Analysis of variance, multivariate logistic regression and a receiver operating characteristic curve analysis were used for statistics.
Hematological indicators and inflammatory markers, including systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ration (NLR), white blood cell, monocytes, and PDW values of NAION patients were notably higher than those of the control groups (p < 0.05). Multivariate logistic regression identified a significant correlation only between higher levels of PDW and NAION (p = 0.001). The optimal cut-off value of PDW was 14.65, featuring 75.9% sensitivity and 66.4% specificity. However, there was no statistical difference between the NAION patients and the controls in ocular parameters.
Inflammatory hematological indicators were significantly increased in NAION patients, and PDW might serve as a new marker for the clinical management of NAION patients.
评估非动脉炎性前部缺血性视神经病变（NAION）患者血液学指标和眼部参数的临床意义。
在这项回顾性研究中，2019年至2024年纳入了31例NAION患者和117例年龄及性别匹配的对照受试者。所有参与者均接受了全面的眼部检查并进行了血常规检查。收集血液学参数（白细胞、中性粒细胞、淋巴细胞、单核细胞、平均血小板体积、血小板分布宽度（PDW）、活化部分凝血活酶时间和国际标准化比值）以及包括眼轴长度和前房深度在内的眼部参数。采用方差分析、多因素逻辑回归和受试者工作特征曲线分析进行统计学处理。
NAION患者的血液学指标和炎症标志物，包括全身免疫炎症指数（SII）、中性粒细胞与淋巴细胞比值（NLR）、白细胞、单核细胞和PDW值均显著高于对照组（p < 0.05）。多因素逻辑回归分析仅发现较高水平的PDW与NAION之间存在显著相关性（p = 0.001）。PDW的最佳截断值为14.65，敏感性为75.9%，特异性为66.4%。然而，NAION患者与对照组在眼部参数方面无统计学差异。
NAION患者的炎症性血液学指标显著升高，PDW可能作为NAION患者临床管理的新标志物。
