与牛淋巴细胞抗原-DRB3易感等位基因的存在相比，感染A组或B-1组的牛白血病病毒对幼牛地方流行性牛白血病的发展影响更大。
Infection with bovine leukemia virus belonging to group A or B-1 contributes more strongly to the development of enzootic bovine leukosis in young cattle than the presence of bovine lymphocyte antigen-DRB3 susceptibility alleles.
作者信息
Fujii Yuki, Maezawa Masaki, Akagami Masataka, Kawakami Junko, Fujimoto Yuri, Inokuma Hisashi
机构信息
Livestock Division, Ibaraki Prefecture Government, Mito, Ibaraki, 310-8555, Japan.
Laboratory of OSG Veterinary Science for Global Disease Management, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, 113-8657, Japan.
出版信息
Arch Virol. 2024 Aug 1;169(8):171. doi: 10.1007/s00705-024-06102-7.
Abstract
In this study, we compared the effects of different bovine leukemia virus (BLV) strains and bovine lymphocyte antigen (BoLA)-DRB3 alleles in cattle with enzootic bovine leukosis (EBL) aged either <3 years or ≥3 years. The frequency of infection with BLV belonging to group A or B-1 in cattle aged <3 years with EBL was significantly higher than that in cattle aged ≥3 years, regardless of which BoLA-DRB3 allele was present. This suggests that infection with group A or B-1 BLV contributes more strongly to the development of EBL in young cattle than the presence of early-EBL-onset susceptibility BoLA-DRB3 alleles.
摘要
在本研究中，我们比较了不同牛白血病病毒（BLV）毒株和牛淋巴细胞抗原（BoLA）-DRB3等位基因对年龄小于3岁或大于等于3岁的地方流行性牛白血病（EBL）牛的影响。无论存在哪种BoLA-DRB3等位基因，年龄小于3岁的EBL牛感染A组或B-1组BLV的频率均显著高于年龄大于等于3岁的牛。这表明，与早期EBL发病易感性BoLA-DRB3等位基因相比，感染A组或B-1组BLV对幼龄牛EBL发生的影响更大。
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