Haraoui Louis-Patrick, Rizk Anthony, Landecker Hannah
Department of Microbiology and Infectious Diseases, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada.
Centre de Recherche Charles-Le Moyne, CISSS Montérégie-Centre, Greenfield Park, QC, Canada.
Hist Philos Life Sci. 2024 Aug 1;46(3):28. doi: 10.1007/s40656-024-00624-8.
Drawing on institutional historical records, interviews and student theses, this article charts the intersection of hospital acquired illness, the emergence of antimicrobial resistance (AMR), environments of armed conflict, and larger questions of social governance in the specific case of the American University of Beirut Medical Center (AUBMC) in Lebanon. Taking a methodological cue from approaches in contemporary scientific work that understand non-clinical settings as a fundamental aspect of the history and development of AMR, we treat the hospital as not just nested in a set of social and environmental contexts, but frequently housing within itself elements of social and environmental history. AMR in Lebanon differs in important ways from the settings in which global protocols for infection control or rubrics for risk factor identification for resistant nosocomial outbreaks were originally generated. While such differences are all too often depicted as failures of low and middle-income countries (LMIC) to maintain universal standards, the historical question before us is quite the reverse: how have the putatively universal rubrics of AMR and hospital infection control failed to take account of social and environmental conditions that clearly matter deeply in the evolution and spread of resistance? Focusing on conditions of war as an organized chaos in which social, environmental and clinical factors shift dramatically, on the social and political topography of patient transfer, and on a missing "meso" level of AMR surveillance between the local and global settings, we show how a multisectoral One Health approach to AMR could be enriched by an answering multisectoral methodology in history, particularly one that unsettles a canonical focus on the story of AMR in the Euro-American context.
本文借鉴机构历史记录、访谈和学生论文,以黎巴嫩贝鲁特美国大学医学中心(AUBMC)为例,梳理了医院获得性疾病、抗菌药物耐药性(AMR)的出现、武装冲突环境以及社会治理等重大问题的交叉情况。从当代科学研究方法中获得启示,这些方法将非临床环境视为AMR历史和发展的基本方面,我们认为医院不仅嵌套于一系列社会和环境背景之中,其自身还常常承载着社会和环境历史的元素。黎巴嫩的AMR情况与最初制定全球感染控制协议或耐药性医院感染暴发风险因素识别标准的环境有很大不同。虽然这些差异常常被描述为低收入和中等收入国家(LMIC)未能维持通用标准,但摆在我们面前的历史问题恰恰相反:AMR和医院感染控制的所谓通用标准是如何未能考虑到在耐药性演变和传播中显然至关重要的社会和环境条件的?聚焦战争状态这一社会、环境和临床因素急剧变化的有组织的混乱状态,关注患者转移的社会和政治地形,以及地方和全球层面之间缺失的AMR监测“中观”层面,我们展示了如何通过历史研究中的多部门方法来丰富AMR的多部门“同一健康”方法,特别是那种打破欧美背景下AMR故事的传统关注点的方法。