Research Institute of Clinical and Experimental Lymphology - Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
Bull Exp Biol Med. 2024 Jun;177(2):271-273. doi: 10.1007/s10517-024-06171-3. Epub 2024 Aug 1.
In female Wistar rats with breast cancer, quantitative changes of pro-oncogenic miRNAs (miR-21, -27a, and -221) and tumor-suppressive miR-429 in the mesenteric lymph node were assessed after photodynamic therapy for breast cancer and after photodynamic therapy followed surgical treatment. The level of pro-oncogenic miR-221 in the mesenteric lymph node decreased, and the level of pro-oncogenic miR-21 increased after photodynamic therapy for breast cancer followed by surgical treatment in comparison with the corresponding parameters after photodynamic therapy alone. The content of tumor-suppressive miR-429 remained reduced, as in the group of animals receiving photodynamic therapy alone.
在患有乳腺癌的雌性 Wistar 大鼠中，评估了乳腺癌光动力疗法后和光动力疗法后手术治疗后肠系膜淋巴结中促癌 miRNA（miR-21、-27a 和 -221）和肿瘤抑制 miR-429 的定量变化。与单独光动力疗法相比，乳腺癌光动力疗法后手术治疗后肠系膜淋巴结中促癌 miR-221 的水平降低，而促癌 miR-21 的水平升高。单独接受光动力疗法的动物组中，肿瘤抑制 miR-429 的含量仍然降低。
