Research Institute of Clinical and Experimental Lymphology - Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
Research Institute of Molecular Biology and Biophysics - Structural Subdivision of the Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia.
Bull Exp Biol Med. 2022 Aug;173(4):444-447. doi: 10.1007/s10517-022-05584-2. Epub 2022 Sep 5.
The expression of microRNA (miR-21, miR-221, miR-27a, and miR-429) was studied normal and tumor breast tissues of female Wistar rats before and after photodynamic therapy. In breast cancer, the levels of oncogenic microRNA (miR-21, miR-221, and miR-27a) were increased, while the level of tumor-suppressing miR-429 was reduced in comparison with the intact group. After photodynamic therapy, suppression of the expression levels of oncogenic microRNAs (miR-21, miR-221, and miR-27a) was noted. The level of tumor-suppressing miR-429 in breast tumor tissues remained reduced, as in the untreated breast cancer group.
研究了光动力疗法前后雌性 Wistar 大鼠正常和肿瘤乳腺组织中 microRNA（miR-21、miR-221、miR-27a 和 miR-429）的表达。在乳腺癌中，与完整组相比，致癌 microRNA（miR-21、miR-221 和 miR-27a）的水平升高，而肿瘤抑制 microRNA-429 的水平降低。光动力治疗后，观察到致癌 microRNAs（miR-21、miR-221 和 miR-27a）的表达水平受到抑制。乳腺肿瘤组织中肿瘤抑制 miR-429 的水平仍保持降低，与未经治疗的乳腺癌组相同。
