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海藻糖二糖对阿尔茨海默病实验模型中小胶质细胞活化和全身炎症指标的影响。

Effect of Trehalose Disaccharide on Activation of Microglia and Indices of Systemic Inflammation in an Experimental Model of Alzheimer's Disease.

机构信息

Mental Health Research Center, Moscow, Russia.

Research Institute of Neurosciences and Medicine, Novosibirsk, Russia.

出版信息

Bull Exp Biol Med. 2024 Jun;177(2):207-211. doi: 10.1007/s10517-024-06157-1. Epub 2024 Aug 2.

DOI:10.1007/s10517-024-06157-1
PMID:39090471
Abstract

In an experimental model of Alzheimer's disease in mice, oral administration of trehalose disaccharide reduces neuroinflammation assessed by the expression level of microglia activation marker Iba1 and affects the neutrophil degranulation activity. A potential anti-inflammatory effect of 4% trehalose solution associated with a decrease in the activity of leukocyte elastase in plasma was revealed.

摘要

在阿尔茨海默病的小鼠实验模型中，海藻糖二糖的口服给药通过微胶质细胞激活标志物 Iba1 的表达水平评估可减少神经炎症，并影响嗜中性粒细胞脱颗粒活性。发现 4%海藻糖溶液具有潜在的抗炎作用，可降低血浆中白细胞弹性蛋白酶的活性。

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本文引用的文献

1
Neutrophils as a potential therapeutic target in Alzheimer's disease.中性粒细胞作为阿尔茨海默病潜在的治疗靶点。
Front Immunol. 2023 Mar 3;14:1123149. doi: 10.3389/fimmu.2023.1123149. eCollection 2023.
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Neuroinflammation in Alzheimer's Disease: Current Progress in Molecular Signaling and Therapeutics.阿尔茨海默病中的神经炎症：分子信号传导与治疗的当前进展
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Disaccharide trehalose in experimental therapies for neurodegenerative disorders: Molecular targets and translational potential.
二糖海藻糖在神经退行性疾病实验治疗中的应用：分子靶点和转化潜力。
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Neutrophil Elastase Increases Vascular Permeability and Leukocyte Transmigration in Cultured Endothelial Cells and Obese Mice.中性粒细胞弹性蛋白酶增加培养的内皮细胞和肥胖小鼠的血管通透性和白细胞迁移。
Cells. 2022 Jul 25;11(15):2288. doi: 10.3390/cells11152288.
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Combined induction of mTOR-dependent and mTOR-independent pathways of autophagy activation as an experimental therapy for Alzheimer's disease-like pathology in a mouse model.联合诱导 mTOR 依赖性和非依赖性自噬激活途径作为一种实验疗法，用于治疗小鼠模型中的阿尔茨海默病样病理。
Pharmacol Biochem Behav. 2022 Jun;217:173406. doi: 10.1016/j.pbb.2022.173406. Epub 2022 May 21.
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Autoantibodies targeting neuronal proteins as biomarkers for neurodegenerative diseases.针对神经原蛋白的自身抗体可作为神经退行性疾病的生物标志物。
Theranostics. 2022 Mar 28;12(7):3045-3056. doi: 10.7150/thno.72126. eCollection 2022.
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The Impact of Systemic Inflammation on Alzheimer's Disease Pathology.系统性炎症对阿尔茨海默病病理的影响。
Front Immunol. 2022 Jan 6;12:796867. doi: 10.3389/fimmu.2021.796867. eCollection 2021.
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Microglia in Alzheimer's Disease: A Target for Therapeutic Intervention.阿尔茨海默病中的小胶质细胞：治疗干预的靶点
Front Cell Neurosci. 2021 Nov 24;15:749587. doi: 10.3389/fncel.2021.749587. eCollection 2021.
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Cellular and molecular mechanism in neurodegeneration: Possible role of neuroprotectants.神经退行性变中的细胞和分子机制：神经保护剂的可能作用。
Cell Biochem Funct. 2021 Jul;39(5):613-622. doi: 10.1002/cbf.3630. Epub 2021 Mar 1.
10
Evaluating the Effects of Grain of Isogenic Wheat Lines Differing in the Content of Anthocyanins in Mouse Models of Neurodegenerative Disorders.评价同基因小麦品系中花色苷含量差异对神经退行性疾病模型小鼠的影响。
Nutrients. 2020 Dec 18;12(12):3877. doi: 10.3390/nu12123877.