du Plessis Jacomina P, Lammertyn Leandi, Schutte Aletta E, Nienaber-Rousseau Cornelie
Centre of Excellence for Nutrition, North-West University, Private bag x6001, Box 594, Nutrition, Potchefstroom, 2520, South Africa.
Hypertension in Africa Research Team, North-West University, Potchefstroom, 2520, South Africa.
Genes Nutr. 2024 Aug 1;19(1):14. doi: 10.1186/s12263-024-00751-8.
We investigated circulating homocysteine (Hcy), a cardiovascular disease (CVD) risk factor, examining its dietary associations to provide personalized nutrition advice. This study addressed the inadequacy of current dietary interventions to ultimately address the disproportionately high incidence of CVD in Black populations.
Cross-sectional analyses of 1,867 Black individuals of the PURE-SA study allowed the identification of dietary intake and cardiovascular measure interactions on three sub-categories: (1) normal blood pressure (BP), hypertension or Hcy-related hypertension (H-type), (2) low, normal or high Hcy concentrations, and (3) Hcy-related genetic combinations. Favorable body composition, but adverse dietary intake and cardiovascular determinants, were observed in higher Hcy categories. H-types, compared to regular hypertensives, had higher alcohol and lower macronutrient and micronutrient consumption. Inverse associations with carotid-radial pulse wave velocity were evident between monounsaturated fatty acid (FA) consumption and H-type hypertension as well as polyunsaturated FA and CBS883/ins68 TT carriers. Energy intake was positively associated with vascular cell adhesion molecule-1 (VCAM-1) in variant CBST883C/ins68 and CBS9276 GG carriers. VCAM-1 was also positively associated with plant protein intake in CBS9276 GG and MTR2756 AA carriers and negatively with total protein intake and CBS9276 GG carriers. Alcohol intake was positively associated with intercellular adhesion molecule-1 in MTR2756 minor allele carriers.
Because Hcy gene-diet interactions are evident, personalized nutrition, by adjusting diets based on genetic profiles (e.g., CBS and MTR variations) and dietary interactions (e.g., FAs and proteins), can enhance cardiovascular outcomes by managing Hcy and related hypertension in genetically susceptible individuals.
我们对循环同型半胱氨酸（Hcy）进行了研究，它是一种心血管疾病（CVD）风险因素，我们探究其与饮食的关联以提供个性化营养建议。本研究解决了当前饮食干预在最终解决黑人人群中CVD发病率过高问题上的不足。
对PURE-SA研究中的1867名黑人个体进行横断面分析，以确定饮食摄入与心血管指标在三个子类别上的相互作用：（1）正常血压（BP）、高血压或Hcy相关高血压（H型）；（2）低、正常或高Hcy浓度；（3）Hcy相关基因组合。在较高Hcy类别中观察到有利的身体成分，但饮食摄入和心血管决定因素不利。与普通高血压患者相比，H型患者饮酒量更高，而常量营养素和微量营养素摄入量更低。单不饱和脂肪酸（FA）摄入与H型高血压之间以及多不饱和脂肪酸与CBS883/ins68 TT携带者之间，与颈-桡脉搏波速度呈负相关。在CBST883C/ins68变体和CBS9276 GG携带者中，能量摄入与血管细胞黏附分子-1（VCAM-1）呈正相关。在CBS9276 GG和MTR2756 AA携带者中，VCAM-1也与植物蛋白摄入呈正相关，而与总蛋白摄入呈负相关，且与CBS9276 GG携带者有关。在MTR2756小等位基因携带者中，酒精摄入与细胞间黏附分子-1呈正相关。
由于Hcy基因与饮食的相互作用明显，通过根据基因谱（如CBS和MTR变异）和饮食相互作用（如脂肪酸和蛋白质）调整饮食的个性化营养，可以通过管理遗传易感个体中的Hcy和相关高血压来改善心血管结局。
