Center of Excellence for Nutrition, North-West University, Potchefstroom, South Africa.
Center of Excellence for Nutrition, North-West University, Potchefstroom, South Africa; Hypertension in Africa Research Team, North-West University, Potchefstroom, South Africa.
J Pediatr. 2021 Jul;234:158-163.e2. doi: 10.1016/j.jpeds.2021.03.034. Epub 2021 Mar 26.
To evaluate the associations between homocysteine (Hcy) and cardiovascular health in South African adolescents.
Circulating Hcy concentrations of 172 South African adolescents (105 girls, ages 13 to <18 years) were measured. Anthropometric and cardiovascular factors were also included and cross-sectionally analyzed through general linear models.
Hcy correlated positively with body weight (P = .03; after adjusting for multiple testing, it was not regarded as significant) and muscle mass (P = .01), but negatively with fibrinogen concentrations (P = .001). Across Hcy tertiles, blood pressure produced approximating U-shaped curves, with differences between the middle and upper tertiles (all P < .02). Forty percent of the adolescents had elevated blood pressure, of whom 37% fell in the lowest and 38% in the highest Hcy tertiles. Hcy differed between the sexes (with boys having higher Hcy), but not between subgroups based on puberty, weight, stunting, smoking, or alcohol consumption.
Both high and low Hcy could be early contributing risk factors to cardiovascular health. The associations between Hcy and blood pressure suggest that dietary and lifestyle manipulation, to achieve the optimal range of Hcy, may be beneficial in preventing Hcy-related hypertension in adulthood. The inverse relationship between Hcy and fibrinogen remains to be clarified.
评估同型半胱氨酸（Hcy）与南非青少年心血管健康之间的关系。
对 172 名南非青少年（105 名女孩，年龄 13 岁至<18 岁）的循环 Hcy 浓度进行了测量。还纳入了人体测量学和心血管因素，并通过一般线性模型进行了横断面分析。
Hcy 与体重呈正相关（P=0.03；经多次检验调整后，不再视为显著相关），与肌肉量呈正相关（P=0.01），但与纤维蛋白原浓度呈负相关（P=0.001）。在 Hcy 三分位组中，血压呈近似 U 型曲线，中值和高值三分位组之间存在差异（均 P<0.02）。40%的青少年血压升高，其中 37%处于最低 Hcy 三分位组，38%处于最高 Hcy 三分位组。Hcy 在性别之间存在差异（男孩的 Hcy 水平较高），但在青春期、体重、发育迟缓、吸烟或饮酒等亚组之间无差异。
高同型半胱氨酸和低同型半胱氨酸都可能是心血管健康的早期危险因素。Hcy 与血压之间的关系表明，通过饮食和生活方式的干预，使 Hcy 达到最佳范围，可能有益于预防成年后与 Hcy 相关的高血压。Hcy 与纤维蛋白原之间的负相关关系仍有待阐明。
