Ye Mudan, Yeh John, Kosteria Ioanna, Li Li
Department of Gynecology and Obstetrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Department of Gynecology, Obstetrics and Reproductive Biology, Harvard Medical School, Boston, MA, United States.
Front Med (Lausanne). 2020 Jan 24;7:3. doi: 10.3389/fmed.2020.00003. eCollection 2020.
Growth retardation and gonadal dysgenesis are two of the most important clinical manifestations of Turner syndrome (TS). As premature ovarian failure generally occurs early in life in women with TS, these patients should be counseled and evaluated as early as possible for discussion of optimal and individualized fertility preservation strategies. Infertility seriously affects the quality of life of women with TS. For those who have ovarian reserve, the theoretical options for future fertility in TS patients include cryopreservation of oocytes, ovarian tissues, and embryos. For those who have already lost their ovarian reserve, oocyte or embryo donation, gestational surrogacy, and adoption are strategies that allow fulfillment of desire for parenting. This review describes the etiologies of infertility and reviews the fertility preservation strategies for women with TS.
生长发育迟缓与性腺发育不全是特纳综合征(TS)最重要的两种临床表现。由于卵巢早衰通常在患有TS的女性早年就会发生,因此应尽早为这些患者提供咨询和评估,以便讨论最佳的个体化生育力保存策略。不孕严重影响了TS女性的生活质量。对于那些有卵巢储备功能的患者,TS患者未来生育的理论选择包括冷冻保存卵母细胞、卵巢组织和胚胎。对于那些已经失去卵巢储备功能的患者,卵母细胞或胚胎捐赠、代孕和领养是实现为人父母愿望的策略。本综述描述了不孕的病因,并回顾了TS女性的生育力保存策略。