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结直肠癌筛查策略的优化:新见解。

Optimization of colorectal cancer screening strategies: New insights.

机构信息

Department of Nutrition and Public Health, Holy Spirit University of Kaslik, Jounieh 446, Lebanon.

Department of Internal Medicine, Ain Wazein Medical Village, Chouf 1503, Lebanon.

出版信息

World J Gastroenterol. 2024 Jul 28;30(28):3361-3366. doi: 10.3748/wjg.v30.i28.3361.

DOI:10.3748/wjg.v30.i28.3361
PMID:39091719
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11290395/
Abstract

In this editorial, we discuss the article by Agatsuma . We concentrate specifically on the current routinely used screening tests recommended by society guidelines and delve into the significance of early diagnosis of colorectal cancer (CRC) and its substantial impact on both incidence and mortality rates. Screening is highly recommended, and an early diagnosis stands out as the most crucial predictor of survival for CRC patients. Therefore, it is essential to identify and address the barriers hindering adherence to screening measures, as these barriers can vary among different populations. Furthermore, we focus on screening strategy optimization by selecting high-risk groups. Patients with comorbidities who regularly visit hospitals have been diagnosed at an early stage, showing no significant difference compared to patients undergoing regular screening. This finding highlights the importance of extending screening measures to include patients with comorbidities who do not routinely visit the hospital.

摘要

在这篇社论中,我们讨论了 Agatsuma 的文章。我们特别关注目前社会指南推荐的常规使用的筛查试验,并深入探讨了早期诊断结直肠癌(CRC)的意义及其对发病率和死亡率的重大影响。筛查是高度推荐的,早期诊断是 CRC 患者生存的最关键预测因素。因此,必须确定并解决阻碍筛查措施依从性的障碍,因为这些障碍在不同人群中可能有所不同。此外,我们通过选择高危人群来关注筛查策略的优化。经常去医院就诊的伴有合并症的患者已经被早期诊断,与定期接受筛查的患者相比没有显著差异。这一发现强调了将筛查措施扩展到不经常去医院的伴有合并症患者的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8221/11290395/7b6166545645/WJG-30-3361-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8221/11290395/7b6166545645/WJG-30-3361-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8221/11290395/7b6166545645/WJG-30-3361-g001.jpg

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本文引用的文献

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World J Gastroenterol. 2024 Mar 14;30(10):1368-1376. doi: 10.3748/wjg.v30.i10.1368.
2
Next-Generation Multitarget Stool DNA Test for Colorectal Cancer Screening.用于结直肠癌筛查的下一代多靶点粪便 DNA 检测。
N Engl J Med. 2024 Mar 14;390(11):984-993. doi: 10.1056/NEJMoa2310336.
3
Colorectal cancer screening-what does the recent NordICC trial mean for the U.S. population?结直肠癌筛查——近期的北欧结直肠癌筛查试验对美国人群意味着什么?
Transl Gastroenterol Hepatol. 2023 Aug 30;8:40. doi: 10.21037/tgh-23-20. eCollection 2023.
4
Is there a place for sigmoidoscopy in colorectal cancer screening? A systematic review and critical appraisal of cost-effectiveness models.直肠乙状结肠镜检查在结直肠癌筛查中的地位如何?成本效益模型的系统评价和批判性评估。
PLoS One. 2023 Aug 18;18(8):e0290353. doi: 10.1371/journal.pone.0290353. eCollection 2023.
5
Methylated Septin9 identified patients with colorectal carcinoma and showed higher sensitivity than conventional biomarkers in detecting tumor.甲基化 Septin9 可识别结直肠癌患者,在检测肿瘤方面比传统生物标志物具有更高的敏感性。
Cancer Treat Res Commun. 2023;36:100748. doi: 10.1016/j.ctarc.2023.100748. Epub 2023 Jul 25.
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Barriers and Facilitators to Colorectal Cancer Screening in South Asian Immigrants: A Systematic Review.南亚移民结直肠癌筛查的障碍和促进因素:系统评价。
Asian Pac J Cancer Prev. 2023 May 1;24(5):1463-1475. doi: 10.31557/APJCP.2023.24.5.1463.
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