Kurniawan Roy Bagus, Saputra Pandit Bagus Tri, Haq Alyaa Ulaa Dhiya Ul, Purwati Dinda Dwi, Wungu Citrawati Dyah Kencono, Susilo Hendri, Alsagaff Mochamad Yusuf, Amin Indah Mohd, Oktaviono Yudi Her
Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia - Dr. Soetomo General Academic Hospital, Surabaya, Indonesia.
iScience. 2024 Jun 22;27(7):110351. doi: 10.1016/j.isci.2024.110351. eCollection 2024 Jul 19.
The presence of calcified nodule (CN) is a significant characteristic of atherothrombosis in acute coronary syndrome (ACS). However, its characteristics continue to be understudied. This review aimed to further investigate these characteristics. This study found that CN was a distinctive feature of an atheromatous plaque, representing 6.3% of ACS. CN was more common in NSTE-ACS than in STEMI patients (9.4% vs. 6.6%). CN was also chiefly observed in the left anterior descendant artery (48%), followed by the right coronary (40.4%) and left circumflex (14.5%) arteries. Higher prevalence of hypertension (78.8%), diabetes mellitus (50.8%), multivessel disease (71.7%), and kidney disease (26.43%) were noted in CN compared to non-CN patients. CN-associated ACS also 6-fold increased the risk of target lesion revascularization compared to those without CN.
钙化结节（CN）的存在是急性冠状动脉综合征（ACS）中动脉粥样硬化血栓形成的一个显著特征。然而，其特征仍有待进一步研究。本综述旨在进一步探究这些特征。该研究发现，CN是动脉粥样硬化斑块的一个独特特征，占ACS的6.3%。CN在非ST段抬高型ACS患者中比ST段抬高型心肌梗死（STEMI）患者更常见（9.4%对6.6%）。CN也主要出现在左前降支动脉（48%），其次是右冠状动脉（40.4%）和左旋支动脉（14.5%）。与无CN患者相比，CN患者中高血压（78.8%）、糖尿病（50.8%）、多支血管病变（71.7%）和肾脏疾病（26.43%）的患病率更高。与无CN的患者相比，与CN相关的ACS使靶病变血运重建风险增加了6倍。
