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TMEM16 蛋白：钙激活氯离子通道和磷脂翻转酶作为潜在的药物靶点（综述）。

TMEM16 proteins: Ca‑activated chloride channels and phospholipid scramblases as potential drug targets (Review).

机构信息

Department of Hand and Foot Surgery, Shenzhen Second People's Hospital (The First Hospital Affiliated to Shenzhen University), Shenzhen, Guangdong 518000, P.R. China.

Department of Orthopaedics, Shenzhen Second People's Hospital (The First Hospital Affiliated to Shenzhen University), Shenzhen, Guangdong 518000, P.R. China.

出版信息

Int J Mol Med. 2024 Oct;54(4). doi: 10.3892/ijmm.2024.5405. Epub 2024 Aug 2.

DOI:10.3892/ijmm.2024.5405
PMID:39092585
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11315658/
Abstract

TMEM16 proteins, which function as Ca‑activated Cl channels are involved in regulating a wide variety of cellular pathways and functions. The modulators of Cl channels can be used for the molecule‑based treatment of respiratory diseases, cystic fibrosis, tumors, cancer, osteoporosis and coronavirus disease 2019. The TMEM16 proteins link Ca signaling, cellular electrical activity and lipid transport. Thus, deciphering these complex regulatory mechanisms may enable a more comprehensive understanding of the physiological functions of the TMEM16 proteins and assist in ascertaining the applicability of these proteins as potential pharmacological targets for the treatment of a range of diseases. The present review examined the structures, functions and characteristics of the different types of TMEM16 proteins, their association with the pathogenesis of various diseases and the applicability of TMEM16 modulator‑based treatment methods.

摘要

TMEM16 蛋白作为 Ca2+激活的氯离子通道，参与调节多种细胞通路和功能。氯离子通道调节剂可用于基于分子的呼吸系统疾病、囊性纤维化、肿瘤、癌症、骨质疏松症和 2019 年冠状病毒病的治疗。TMEM16 蛋白连接 Ca2+信号、细胞电活动和脂质转运。因此，破译这些复杂的调控机制可能使人们更全面地了解 TMEM16 蛋白的生理功能，并有助于确定这些蛋白作为治疗一系列疾病的潜在药理学靶点的适用性。本综述探讨了不同类型 TMEM16 蛋白的结构、功能和特性，以及它们与各种疾病发病机制的关系，以及 TMEM16 调节剂治疗方法的适用性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d30d/11315658/7eae9809b892/ijmm-54-04-05405-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d30d/11315658/48af76425f79/ijmm-54-04-05405-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d30d/11315658/7ce2a7beb287/ijmm-54-04-05405-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d30d/11315658/426aa9753dd1/ijmm-54-04-05405-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d30d/11315658/a76d71426ec4/ijmm-54-04-05405-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d30d/11315658/f3fe3aab4eb0/ijmm-54-04-05405-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d30d/11315658/838749df8388/ijmm-54-04-05405-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d30d/11315658/7eae9809b892/ijmm-54-04-05405-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d30d/11315658/48af76425f79/ijmm-54-04-05405-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d30d/11315658/7ce2a7beb287/ijmm-54-04-05405-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d30d/11315658/426aa9753dd1/ijmm-54-04-05405-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d30d/11315658/a76d71426ec4/ijmm-54-04-05405-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d30d/11315658/f3fe3aab4eb0/ijmm-54-04-05405-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d30d/11315658/838749df8388/ijmm-54-04-05405-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d30d/11315658/7eae9809b892/ijmm-54-04-05405-g06.jpg

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J Clin Invest. 2023 Jun 1;133(11):e170643. doi: 10.1172/JCI170643.
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A novel ANO3 variant in two siblings with different phenotypes.两同胞兄妹表型不同，携带一种新型ANO3 变异。
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The effects of elexafactor/tezafactor/ivacaftor beyond the epithelium: spurring macrophages to fight infections.依列卡因子/替扎因子/依伐卡托在肺上皮细胞之外的作用：刺激巨噬细胞对抗感染
Eur Respir J. 2023 Apr 1;61(4). doi: 10.1183/13993003.00216-2023. Print 2023 Apr.
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Genetic disruption of Ano5 leads to impaired osteoclastogenesis for gnathodiaphyseal dysplasia.Ano5 基因缺失导致颌骨-骨干发育不良的破骨细胞生成受损。
Oral Dis. 2024 Apr;30(3):1403-1415. doi: 10.1111/odi.14562. Epub 2023 Mar 29.
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