Central Research Institute of Tuberculosis, Moscow, Russia.
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V. I. Kulakov, Ministry of Health of the Russian Federation, Moscow, Russia.
Bull Exp Biol Med. 2024 Jun;177(2):256-260. doi: 10.1007/s10517-024-06168-y. Epub 2024 Aug 2.
The study revealed no effects of pregnancy and childbirth on the course of tuberculosis in female BALB/c mice after aerosol infection with Mycobacterium tuberculosis. However, we demonstrated a negative effect of tuberculosis infection on the fertility of infected females, which manifested in a longer period from mating to pregnancy and in a smaller litter size. Impaired reproductive function in response to the effect of the systemic infectious process was accompanied by the development of immunosuppression confirmed by an immunological test (delayed-type hypersensitivity to tuberculin) and the formation of genital tract dysbiosis during pregnancy and postpartum period.
该研究揭示了妊娠和分娩对经气溶胶感染结核分枝杆菌的 BALB/c 雌性小鼠结核病病程的无影响。然而，我们证明了结核感染对感染雌性的生育力有负面影响，表现为从交配到怀孕的时间更长，产仔数更少。生殖功能受损是对全身感染过程影响的反应，这一点得到了免疫学检测（结核菌素迟发型超敏反应）的证实，并且在怀孕期间和产后期间形成了生殖道微生态失调。
