[Central hemodynamic function and the metabolic electrolyte ratio of patients with hypertension and hereditary disposition].

A study was made of the pecularities of a course of arterial hypertension and the efficacy of hypotensive therapy in 69 hypertension patients with hereditary aggravation and 92 hypertension patients without hereditary aggravation. In 91 the content and distribution of sodium, potassium and water were studied using radionuclides; indices of the central and renal hemodynamics, plasma renin activity, aldosterone concentration and catecholamine excretion with urine were also studied. A natriuretic reaction to i.v. injection of lasix was measured in 12 of 42 patients. In hereditary aggravation hypertension was characterized by a higher level of systolic and diastolic AP which was more pronounced in men. Higher doses of hemiton and beta-adrenoblocking agents were required for its return to normal. In the authors' opinion, a more severe course of hypertension in such patients was associated with a raised sensitivity of resistant vessels to angiotensin which was confirmed by a significant elevation of the sodium/renin index. Changes in the values of the ratio extra/intracellular content of sodium and potassium in the patients with and without hereditary aggravation were not noticeable. Response to lasix was excessive as compared to normotonics in both groups.