State Key Laboratory for Pollution Control and Resource Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China.
State Key Laboratory for Pollution Control and Resource Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China.
J Environ Sci (China). 2025 Feb;148:614-624. doi: 10.1016/j.jes.2024.01.044. Epub 2024 Feb 10.
The overuse of antibiotics and antitumor drugs has resulted in more and more extensive pollution of water bodies with organic drugs, causing detrimental ecological effects, which have attracted attention towards effective and sustainable methods for antibiotics and antitumor drug degradation. Here, the hybrid nanomaterial (g-CN@Fe/Pd) was synthesized and used to remove a kind of both an antibiotic and antitumor drug named mitoxantrone (MTX) with 92.0% removal efficiency, and the MTX removal capacity is 450 mg/g. After exposing to the hybrid material the MTX aqueous solution changed color from dark blue to lighter progressively, and LC-UV results of residual solutions show that a new peak at 3.0 min (MTX: 13.2 min) after removal by g-CN@Fe/Pd appears, with the simultaneous detection of intermediate products indicating that g-CN@Fe/Pd indeed degrades MTX. Detailed mass spectrometric analysis suggests that the nuclear mass ratio decreased from 445.2 (M1H) to 126.0 (M1H), 169.1 (M1H), 239.2 (M1H), 267.3 (M1H), 285.2 (M1H), 371.4 (M1H) and 415.2 (M1H), and the maximum proportion (5.63%) substance of all degradation products (126.0 (M1H)) is 40-100 times less toxic than MTX. A mechanism for the removal and degradation of mitoxantrone was proposed. Besides, actual water experiments confirmed that the maximum removal capacity of MTX by g-CN@Fe/Pd is up to 492.4 mg/g (0.02 g/L, 10 ppm).
抗生素和抗肿瘤药物的过度使用导致水体中有机药物的污染越来越广泛，对生态造成了有害影响，因此需要寻找有效和可持续的抗生素和抗肿瘤药物降解方法。在这里，合成了一种混合纳米材料（g-CN@Fe/Pd），并用于去除一种抗生素和抗肿瘤药物米托蒽醌（MTX），去除效率达到 92.0%，去除容量为 450mg/g。将 MTX 水溶液暴露于混合材料后，颜色从深蓝色逐渐变为浅色，残留溶液的 LC-UV 结果表明，用 g-CN@Fe/Pd 去除后在 3.0min 处出现新峰（MTX：13.2min），同时检测到中间产物表明 g-CN@Fe/Pd 确实降解了 MTX。详细的质谱分析表明，核质量比从 445.2（M1H）降至 126.0（M1H）、169.1（M1H）、239.2（M1H）、267.3（M1H）、285.2（M1H）、371.4（M1H）和 415.2（M1H），所有降解产物中最大比例（5.63%）的物质（126.0（M1H））的毒性比 MTX 低 40-100 倍。提出了一种去除和降解米托蒽醌的机制。此外，实际水实验证实，g-CN@Fe/Pd 对 MTX 的最大去除容量高达 492.4mg/g（0.02g/L，10ppm）。
