Soliz-Rueda Jorge R, Cuesta-Marti Cristina, O'Mahony Siobhain M, Clarke Gerard, Schellekens Harriët, Muguerza Begoña
Nutrigenomics Research Group, Department of Biochemistry and Biotechnology, Universitat Rovira I Virgili, Reus, Spain; Institut d'Investigació Sanitària Pere Virgili (IISPV), Reus, Spain; Center of Environmental, Food and Toxicological Technology (TecnATox), Tarragona, Spain.
Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland; APC Microbiome Ireland, Cork, Ireland.
Trends Endocrinol Metab. 2025 Jan;36(1):15-28. doi: 10.1016/j.tem.2024.07.008. Epub 2024 Aug 1.
Eating behaviour and circadian rhythms are closely related. The type, timing, and quantity of food consumed, and host circadian rhythms, directly influence the intestinal microbiota, which in turn impacts host circadian rhythms and regulates food intake beyond homeostatic eating. This Opinion discusses the impact of food intake and circadian disruptions induced by an obesogenic environment on gut-brain axis signalling. We also explore potential mechanisms underlying the effects of altered gut microbiota on food intake behaviour and circadian rhythmicity. Understanding the crosstalk between gut microbiota, circadian rhythms, and unhealthy eating behaviour is crucial to addressing the obesity epidemic, which remains one of the biggest societal challenges of our time.
饮食行为与昼夜节律密切相关。所摄入食物的类型、时间和数量，以及宿主的昼夜节律，直接影响肠道微生物群，而肠道微生物群反过来又会影响宿主的昼夜节律，并在稳态饮食之外调节食物摄入。本观点讨论了由致肥胖环境引起的食物摄入和昼夜节律紊乱对肠-脑轴信号传导的影响。我们还探讨了肠道微生物群改变对食物摄入行为和昼夜节律性影响的潜在机制。了解肠道微生物群、昼夜节律和不健康饮食行为之间的相互作用对于应对肥胖流行至关重要，肥胖仍然是我们这个时代最大的社会挑战之一。
