Laboratory of RNA Archaeology, Instituto de Parasitología y Biomedicina "López-Neyra" (CSIC), Avd. Conocimiento 17, 18016, Armilla, Granada, Spain.
Centro de Biología Molecular "Severo Ochoa" (CSIC-UAM), Campus de Cantoblanco, Madrid, Spain.
Sci Rep. 2024 Aug 2;14(1):17914. doi: 10.1038/s41598-024-68760-6.
The rhizome concept proposed by Gilles Deleuze and Félix Guattari offers a novel perspective on the organization and interdependence of complex constellations of heterogeneous entities, their mapping and their ruptures. The emphasis of the present study is placed on the dynamics of contacts and communication among such entities that arise from experimentation, without any favored hierarchy or origin. When applied to biological evolution, the rhizome concept integrates all types of heterogeneity resulting from "symbiotic" relationships among living beings (or their genomic material), horizontal genetic transfer, recombination and mutation, and breaks away from the approach that gives rise to the phylogenetic tree of life. It has already been applied to describe the dynamics and evolution of RNA viruses. Thus, here we introduce a novel framework for the interpretation the viral quasispecies concept, which explains the evolution of RNA virus populations as the result of dynamic interconnections and multifaceted interdependence between highly heterogeneous viral sequences and its inherently heterogeneous host cells. The rhizome network perspective underlines even further the medical implications of the broad mutant spectra of viruses that are in constant flow, given the multiple pathways they have available for fitness loss and gain.
德勒兹和瓜塔里提出的根茎概念为复杂异质实体的组织和相互依存关系、它们的映射和它们的断裂提供了一个新的视角。本研究的重点是强调从实验中产生的这些实体之间的接触和交流的动态，而没有任何有利的层次结构或起源。当应用于生物进化时，根茎概念整合了所有类型的异质性，这些异质性是由生物（或其基因组物质）之间的“共生”关系、水平基因转移、重组和突变产生的，并摆脱了导致生命系统发育树的方法。它已经被应用于描述 RNA 病毒的动态和进化。因此，在这里，我们引入了一个新的框架来解释病毒准种概念，该框架将 RNA 病毒群体的进化解释为高度异质的病毒序列与其固有异质宿主细胞之间的动态互联和多方面相互依存的结果。鉴于病毒具有多种适应度损失和获得的途径，根茎网络视角进一步强调了不断流动的病毒广泛突变谱的医学意义。
