生物材料辅助癌症疫苗传递：临床前景观、挑战和机遇。
Biomaterials-assisted cancer vaccine delivery: preclinical landscape, challenges, and opportunities.
机构信息
Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, China.
College of Pharmacy, Jinan University, Guangzhou, China.
出版信息
Expert Opin Drug Deliv. 2024 Jul;21(7):1143-1154. doi: 10.1080/17425247.2024.2388832. Epub 2024 Aug 17.
INTRODUCTION
Cancer vaccines (protein and peptide, DNA, mRNA, and tumor cell) have achieved remarkable success in the treatment of cancer. In particular, advances in the design and manufacture of biomaterials have made it possible to control the presentation and delivery of vaccine components to immune cells.
AREAS COVERED
This review summarizes findings from major databases, including PubMed, Scopus, and Web of Science, focusing on articles published between 2005 and 2024 that discuss biomaterials in cancer vaccine delivery.
EXPERT OPINION
The development of cancer vaccines is hindered by several bottlenecks, including low immunogenicity, instability of vaccine components, and challenges in evaluating their clinical efficacy. To transform preclinical successes into viable treatments, it is essential to pursue continued innovation, collaborative research, and address issues related to scalability, regulatory pathways, and clinical validation, ultimately improving outcomes against cancer.
简介
癌症疫苗（蛋白和肽、DNA、mRNA 和肿瘤细胞）在癌症治疗方面取得了显著的成功。特别是，生物材料的设计和制造方面的进展使得控制疫苗成分向免疫细胞的呈递和传递成为可能。
涵盖领域
本综述总结了主要数据库（包括 PubMed、Scopus 和 Web of Science）中的发现，重点关注了 2005 年至 2024 年间发表的讨论癌症疫苗输送中生物材料的文章。
专家意见
癌症疫苗的发展受到几个瓶颈的限制，包括免疫原性低、疫苗成分的不稳定性以及评估其临床疗效的挑战。为了将临床前的成功转化为可行的治疗方法，必须继续进行创新、开展合作研究，并解决与可扩展性、监管途径和临床验证相关的问题，最终改善癌症治疗效果。
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